(-)-trimethyl[(2-{[(1R)-1-methyl-3-(4-methylphenyl)prop-2-yn-1-yl]oxy}phenyl)-ethynyl]silane

Base Information

Chemical Name:(-)-trimethyl[(2-{[(1R)-1-methyl-3-(4-methylphenyl)prop-2-yn-1-yl]oxy}phenyl)-ethynyl]silane
CAS No.:1393671-39-0
Molecular Formula:C₂₂H₂₄OSi
Molecular Weight:332.517
Hs Code.:

Synonyms:(-)-trimethyl[(2-{[(1R)-1-methyl-3-(4-methylphenyl)prop-2-yn-1-yl]oxy}phenyl)-ethynyl]silane

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Chemical Property of (-)-trimethyl[(2-{[(1R)-1-methyl-3-(4-methylphenyl)prop-2-yn-1-yl]oxy}phenyl)-ethynyl]silane

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Technology Process of (-)-trimethyl[(2-{[(1R)-1-methyl-3-(4-methylphenyl)prop-2-yn-1-yl]oxy}phenyl)-ethynyl]silane

There total 1 articles about (-)-trimethyl[(2-{[(1R)-1-methyl-3-(4-methylphenyl)prop-2-yn-1-yl]oxy}phenyl)-ethynyl]silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 81787-62-4
o-((trimethylsilyl)ethynyl)phenol

: 220983-57-3
(–)-(2S)-4-(4-methylphenyl)but-3-yn-2-ol

: 1393671-39-0
(-)-trimethyl[(2-{[(1R)-1-methyl-3-(4-methylphenyl)prop-2-yn-1-yl]oxy}phenyl)-ethynyl]silane

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In benzene; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1002/anie.201108307

Reference yield: 83.0%

: 1393671-39-0
(-)-trimethyl[(2-{[(1R)-1-methyl-3-(4-methylphenyl)prop-2-yn-1-yl]oxy}phenyl)-ethynyl]silane

: 1393671-40-3
(+)-1-ethynyl-2-{[(1R)-1-methyl-3-(4-methylphenyl)prop-2-yn-1-yl]oxy}benzene

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃; for 1.5h;
DOI:10.1002/anie.201108307

Reference yield:

: 1393671-39-0
(-)-trimethyl[(2-{[(1R)-1-methyl-3-(4-methylphenyl)prop-2-yn-1-yl]oxy}phenyl)-ethynyl]silane

: (-)-3-{[(1S)-1-methyl-3-(4-methylphenyl)prop-2-yn-1-yl]oxy}-2-[(2-{[(1R)-1-methyl-3-(4-methylphenyl)prop-2-yn-1-yl]oxy}phenyl)ethynyl]-pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / methanol / 1.5 h / 20 °C

2: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diisopropylamine / 6 h / 60 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; diisopropylamine; In methanol; 2: Sonogashira coupling;
DOI:10.1002/anie.201108307