N-(5-chloro-4-fluoro-2-{(E)-3-[3-(4-fluoro-benzyl)-3,8-diaza-bicyclo[3.2.1]oct-8-yl]-3-oxo-propenyl}-phenyl)-acetamide

Base Information

Chemical Name:N-(5-chloro-4-fluoro-2-{(E)-3-[3-(4-fluoro-benzyl)-3,8-diaza-bicyclo[3.2.1]oct-8-yl]-3-oxo-propenyl}-phenyl)-acetamide
CAS No.:868408-80-4
Molecular Formula:C₂₄H₂₄ClF₂N₃O₂
Molecular Weight:459.923
Hs Code.:

Synonyms:N-(5-chloro-4-fluoro-2-{(E)-3-[3-(4-fluoro-benzyl)-3,8-diaza-bicyclo[3.2.1]oct-8-yl]-3-oxo-propenyl}-phenyl)-acetamide

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Chemical Property of N-(5-chloro-4-fluoro-2-{(E)-3-[3-(4-fluoro-benzyl)-3,8-diaza-bicyclo[3.2.1]oct-8-yl]-3-oxo-propenyl}-phenyl)-acetamide

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Technology Process of N-(5-chloro-4-fluoro-2-{(E)-3-[3-(4-fluoro-benzyl)-3,8-diaza-bicyclo[3.2.1]oct-8-yl]-3-oxo-propenyl}-phenyl)-acetamide

There total 5 articles about N-(5-chloro-4-fluoro-2-{(E)-3-[3-(4-fluoro-benzyl)-3,8-diaza-bicyclo[3.2.1]oct-8-yl]-3-oxo-propenyl}-phenyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 417727-43-6
3-(4-fluoro-benzyl)-3,8-diaza-bicyclo[3.2.1]octane

: 868407-62-9
(E)-3-(2-acetylamino-4-chloro-5-fluoro-phenyl)-acrylic acid

: 868408-80-4
N-(5-chloro-4-fluoro-2-{(E)-3-[3-(4-fluoro-benzyl)-3,8-diaza-bicyclo[3.2.1]oct-8-yl]-3-oxo-propenyl}-phenyl)-acetamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 16h;

Reference yield:

: 85462-63-1
N-(2-bromo-5-chloro-4-fluoro-phenyl)-acetamide

: 868408-80-4
N-(5-chloro-4-fluoro-2-{(E)-3-[3-(4-fluoro-benzyl)-3,8-diaza-bicyclo[3.2.1]oct-8-yl]-3-oxo-propenyl}-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / DMF (N,N-dimethyl-formamide) / 16 h / 100 °C

2: trifluoroacetic acid / dichloromethane / 0.5 h

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / DMF (N,N-dimethyl-formamide) / 16 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; palladium diacetate; tris-(o-tolyl)phosphine; In DMF (N,N-dimethyl-formamide); dichloromethane;

Reference yield:

: 90673-35-1
3,8-diazabicyclo[3.2.1]octane dihydrochloride

: 868408-80-4
N-(5-chloro-4-fluoro-2-{(E)-3-[3-(4-fluoro-benzyl)-3,8-diaza-bicyclo[3.2.1]oct-8-yl]-3-oxo-propenyl}-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / ethanol / 2.5 h / Heating / reflux

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / DMF (N,N-dimethyl-formamide) / 16 h / 20 °C

With sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In DMF (N,N-dimethyl-formamide); ethanol;