2-(4-fluorobenzyl)-2,3,6,7-tetrahydro-9,10-dimethoxy-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one hydrochloride

Base Information

• Chemical Name: 2-(4-fluorobenzyl)-2,3,6,7-tetrahydro-9,10-dimethoxy-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one hydrochloride
• CAS No.: 1240039-29-5
• Molecular Formula: C₂₁H₂₃FN₂O₃*ClH
• Molecular Weight: 406.885
• Mol file: 1240039-29-5.mol

Synonyms:2-(4-fluorobenzyl)-2,3,6,7-tetrahydro-9,10-dimethoxy-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one hydrochloride

Chemical Property of 2-(4-fluorobenzyl)-2,3,6,7-tetrahydro-9,10-dimethoxy-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-fluorobenzyl)-2,3,6,7-tetrahydro-9,10-dimethoxy-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one hydrochloride

There total 4 articles about 2-(4-fluorobenzyl)-2,3,6,7-tetrahydro-9,10-dimethoxy-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.1%

4-Fluorobenzyl bromide (459-46-1) + (+/-)-4-oxo-9,10-dimethoxy-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline (90142-16-8) → 2-(4-fluorobenzyl)-2,3,6,7-tetrahydro-9,10-dimethoxy-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one hydrochloride (1240039-29-5)

Guidance literature:

4-Fluorobenzyl bromide; (+/-)-4-oxo-9,10-dimethoxy-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline; With potassium carbonate; In acetone; for 6h; Reflux;

With hydrogenchloride; In water;

DOI:10.1002/ardp.200900279

Reference yield:

C16H26N2O5*ClH (97004-06-3) → 2-(4-fluorobenzyl)-2,3,6,7-tetrahydro-9,10-dimethoxy-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one hydrochloride (1240039-29-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / dichloromethane / 3.5 h / 5 °C

2: potassium carbonate / acetone / 6 h / Reflux

With sulfuric acid; potassium carbonate; In dichloromethane; acetone;

DOI:10.1002/ardp.200900279

Reference yield:

2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → 2-(4-fluorobenzyl)-2,3,6,7-tetrahydro-9,10-dimethoxy-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one hydrochloride (1240039-29-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / dichloromethane / 0 - 10 °C

2.1: toluene / Reflux

2.2: -30 °C

3.1: sulfuric acid / dichloromethane / 3.5 h / 5 °C

4.1: potassium carbonate / acetone / 6 h / Reflux

With sulfuric acid; sodium hydrogencarbonate; potassium carbonate; In dichloromethane; acetone; toluene;

DOI:10.1002/ardp.200900279

upstream raw materials:

C₁₆H₂₆N₂O₅*ClH

2-chloro-N-(2-(3,4-dimethoxyphenyl)ethyl)acetamide

2-(3,4-dimethoxyphenyl)-ethylamine

4-Fluorobenzyl bromide