9-(2-benzyloxy-ethyl)-6-fluoro-2,3,4,9-tetrahydro-1H-carbazole-4-carboxylic acid diethylamide

Base Information

Chemical Name:9-(2-benzyloxy-ethyl)-6-fluoro-2,3,4,9-tetrahydro-1H-carbazole-4-carboxylic acid diethylamide
CAS No.:1246453-91-7
Molecular Formula:C₂₆H₃₁FN₂O₂
Molecular Weight:422.543
Hs Code.:

Synonyms:9-(2-benzyloxy-ethyl)-6-fluoro-2,3,4,9-tetrahydro-1H-carbazole-4-carboxylic acid diethylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 9-(2-benzyloxy-ethyl)-6-fluoro-2,3,4,9-tetrahydro-1H-carbazole-4-carboxylic acid diethylamide

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Technology Process of 9-(2-benzyloxy-ethyl)-6-fluoro-2,3,4,9-tetrahydro-1H-carbazole-4-carboxylic acid diethylamide

There total 10 articles about 9-(2-benzyloxy-ethyl)-6-fluoro-2,3,4,9-tetrahydro-1H-carbazole-4-carboxylic acid diethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 173154-19-3
2-benzyloxy-N-(4-fluoro-phenyl)-acetamide

: 1246453-90-6
3-bromo-2-oxo-cyclohexanecarboxylic acid diethylamide

: 1246453-91-7
9-(2-benzyloxy-ethyl)-6-fluoro-2,3,4,9-tetrahydro-1H-carbazole-4-carboxylic acid diethylamide

Guidance literature:: With zinc(II) chloride; In isopropyl alcohol; at 50 ℃; for 19h; Inert atmosphere; Reflux;

Reference yield:

: 1655-07-8
ethyl 2-oxocyclohexane carboxylate

: 1246453-91-7
9-(2-benzyloxy-ethyl)-6-fluoro-2,3,4,9-tetrahydro-1H-carbazole-4-carboxylic acid diethylamide

Guidance literature:: Multi-step reaction with 3 steps

1: dmap / toluene / 72 h / Reflux

2: bromine / diethyl ether / 3.25 h / 0 - 20 °C / Inert atmosphere

3: zinc(II) chloride / isopropyl alcohol / 19 h / 50 °C / Inert atmosphere; Reflux

With dmap; bromine; zinc(II) chloride; In diethyl ether; isopropyl alcohol; toluene;

Reference yield:

: 30379-55-6
benzyloxyacetic acid

: 1246453-91-7
9-(2-benzyloxy-ethyl)-6-fluoro-2,3,4,9-tetrahydro-1H-carbazole-4-carboxylic acid diethylamide

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 5 h / 20 °C

2: triethylamine / dichloromethane / 20 °C

3: zinc(II) chloride / isopropyl alcohol / 19 h / 50 °C / Inert atmosphere; Reflux

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; zinc(II) chloride; In dichloromethane; isopropyl alcohol;