2-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}-2-cyclopropylmethoxyethanol

Base Information

Chemical Name:2-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}-2-cyclopropylmethoxyethanol
CAS No.:1429879-09-3
Molecular Formula:C₂₃H₂₂ClNO₂
Molecular Weight:379.886
Hs Code.:

Synonyms:2-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}-2-cyclopropylmethoxyethanol

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Chemical Property of 2-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}-2-cyclopropylmethoxyethanol

Chemical Property:

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Technology Process of 2-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}-2-cyclopropylmethoxyethanol

There total 2 articles about 2-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}-2-cyclopropylmethoxyethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.5%

: 2516-33-8
Cyclopropylmethanol

: 1429879-00-4
7-chloro-2-[(E)-2-(3-oxiranylphenyl)vinyl]quinoline

: 1429879-09-3
2-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}-2-cyclopropylmethoxyethanol

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at 20 - 30 ℃; for 18h;

Reference yield:

: 120578-03-2
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde

: 1429879-09-3
2-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}-2-cyclopropylmethoxyethanol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride; trimethylsulphonium iodide / tetrahydrofuran / 2 h / Inert atmosphere

2: boron trifluoride diethyl etherate / dichloromethane / 18 h / 20 - 30 °C

With boron trifluoride diethyl etherate; trimethylsulphonium iodide; sodium hydride; In tetrahydrofuran; dichloromethane;