1-{(2R,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-hydroxymethyl-tetrahydro-furan-2-ylmethyl}-5-methyl-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:1-{(2R,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-hydroxymethyl-tetrahydro-furan-2-ylmethyl}-5-methyl-1H-pyrimidine-2,4-dione
CAS No.:184719-33-3
Molecular Formula:C₃₂H₃₄N₂O₇
Molecular Weight:558.631
Hs Code.:

Synonyms:1-{(2R,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-hydroxymethyl-tetrahydro-furan-2-ylmethyl}-5-methyl-1H-pyrimidine-2,4-dione

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Chemical Property of 1-{(2R,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-hydroxymethyl-tetrahydro-furan-2-ylmethyl}-5-methyl-1H-pyrimidine-2,4-dione

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Technology Process of 1-{(2R,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-hydroxymethyl-tetrahydro-furan-2-ylmethyl}-5-methyl-1H-pyrimidine-2,4-dione

There total 10 articles about 1-{(2R,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-hydroxymethyl-tetrahydro-furan-2-ylmethyl}-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-[(2R,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-ylmethyl]-5-methyl-1H-pyrimidine-2,4-dione

: 184719-33-3
1-{(2R,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-hydroxymethyl-tetrahydro-furan-2-ylmethyl}-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 2h; Yield given;
DOI:10.1021/jo961548k

Reference yield:

: 132151-65-6
(E)-3-methoxy-2-methylacryloyl isocyanate

: 184719-33-3
1-{(2R,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-hydroxymethyl-tetrahydro-furan-2-ylmethyl}-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / benzene / 16 h / 25 °C

2: conc. HCl / acetic acid / 16 h / 25 °C

3: KOH / ethanol; H₂O / 25 °C

4: imidazole / dimethylformamide / 1 h / 25 °C

5: DMAP / pyridine / 25 °C

6: n-Bu₄NF / tetrahydrofuran / 2 h / 25 °C

With 1H-imidazole; hydrogenchloride; dmap; potassium hydroxide; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; pyridine; ethanol; water; acetic acid; N,N-dimethyl-formamide; benzene;
DOI:10.1016/0960-894X(95)00589-L

Reference yield:

: 170983-96-7
2,5-anhydro-3-deoxy-1-(thymin-1-yl)-D-ribo-hexitol

: 184719-33-3
1-{(2R,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-hydroxymethyl-tetrahydro-furan-2-ylmethyl}-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: imidazole / dimethylformamide / 1 h / 25 °C

2: DMAP / pyridine / 25 °C

3: n-Bu₄NF / tetrahydrofuran / 2 h / 25 °C

With 1H-imidazole; dmap; tetrabutyl ammonium fluoride; In tetrahydrofuran; pyridine; N,N-dimethyl-formamide;
DOI:10.1016/0960-894X(95)00589-L