(3S)-3-(3,4-dimethoxyphenyl)-8,8-dimethyl-2,3-dihydro-4H,8H-pyrano[2,3-f]chromen-4-one

Base Information

Chemical Name:(3S)-3-(3,4-dimethoxyphenyl)-8,8-dimethyl-2,3-dihydro-4H,8H-pyrano[2,3-f]chromen-4-one
CAS No.:1386350-26-0
Molecular Formula:C₂₂H₂₂O₅
Molecular Weight:366.414
Hs Code.:

Synonyms:(3S)-3-(3,4-dimethoxyphenyl)-8,8-dimethyl-2,3-dihydro-4H,8H-pyrano[2,3-f]chromen-4-one

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Chemical Property of (3S)-3-(3,4-dimethoxyphenyl)-8,8-dimethyl-2,3-dihydro-4H,8H-pyrano[2,3-f]chromen-4-one

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Technology Process of (3S)-3-(3,4-dimethoxyphenyl)-8,8-dimethyl-2,3-dihydro-4H,8H-pyrano[2,3-f]chromen-4-one

There total 18 articles about (3S)-3-(3,4-dimethoxyphenyl)-8,8-dimethyl-2,3-dihydro-4H,8H-pyrano[2,3-f]chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: (S)-2-(3,4-dimethoxyphenyl)-3-hydroxy-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)propan-1-one

: 1386350-26-0
(3S)-3-(3,4-dimethoxyphenyl)-8,8-dimethyl-2,3-dihydro-4H,8H-pyrano[2,3-f]chromen-4-one

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; Inert atmosphere;

Reference yield:

: 1386351-25-2
5-(2-methylbut-3-yn-2-yloxy)-2-nitrophenol

: 1386350-26-0
(3S)-3-(3,4-dimethoxyphenyl)-8,8-dimethyl-2,3-dihydro-4H,8H-pyrano[2,3-f]chromen-4-one

Guidance literature:: Multi-step reaction with 8 steps

1: N,N-dimethyl-aniline / 130 °C / Inert atmosphere

2: potassium carbonate / acetone / 55 °C

3: tin(II) chloride dihdyrate / ethanol / 1 h / Heating; Inert atmosphere

4: hydrogen bromide / water / 0.17 h / 0 °C

5: n-butyllithium / tetrahydrofuran / 0.83 h / -78 - 20 °C

6: Dess-Martin periodane / dichloromethane / 1 h

7: boron trichloride / dichloromethane / 1 h / -78 °C

8: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / Inert atmosphere

With n-butyllithium; tin(II) chloride dihdyrate; di-isopropyl azodicarboxylate; hydrogen bromide; boron trichloride; potassium carbonate; Dess-Martin periodane; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-aniline; acetone;

Reference yield:

: 1386351-26-3
2,2-dimethyl-6-nitro-2H-chromen-5-ol

: 1386350-26-0
(3S)-3-(3,4-dimethoxyphenyl)-8,8-dimethyl-2,3-dihydro-4H,8H-pyrano[2,3-f]chromen-4-one

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / acetone / 55 °C

2: tin(II) chloride dihdyrate / ethanol / 1 h / Heating; Inert atmosphere

3: hydrogen bromide / water / 0.17 h / 0 °C

4: n-butyllithium / tetrahydrofuran / 0.83 h / -78 - 20 °C

5: Dess-Martin periodane / dichloromethane / 1 h

6: boron trichloride / dichloromethane / 1 h / -78 °C

7: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / Inert atmosphere

With n-butyllithium; tin(II) chloride dihdyrate; di-isopropyl azodicarboxylate; hydrogen bromide; boron trichloride; potassium carbonate; Dess-Martin periodane; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; water; acetone;