3-{6-((2-chlorophenyl)methoxy)-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-yl}propanoic acid trifluoroacetic acid

Base Information

Chemical Name:3-{6-((2-chlorophenyl)methoxy)-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-yl}propanoic acid trifluoroacetic acid
CAS No.:1355086-06-4
Molecular Formula:C₂HF₃O₂*C₂₂H₂₄ClNO₄
Molecular Weight:515.914
Hs Code.:

Synonyms:3-{6-((2-chlorophenyl)methoxy)-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-yl}propanoic acid trifluoroacetic acid

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Chemical Property of 3-{6-((2-chlorophenyl)methoxy)-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-yl}propanoic acid trifluoroacetic acid

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Technology Process of 3-{6-((2-chlorophenyl)methoxy)-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-yl}propanoic acid trifluoroacetic acid

There total 8 articles about 3-{6-((2-chlorophenyl)methoxy)-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-yl}propanoic acid trifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1355091-05-2
tert-butyl 3-{6-[(2-chlorophenyl)methoxy]-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-yl}propanoate

: 76-05-1
trifluoroacetic acid

: 1355086-06-4
3-{6-((2-chlorophenyl)methoxy)-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-yl}propanoic acid trifluoroacetic acid

Guidance literature:: In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1355087-94-3
2H-spiro(1-benzofuran-3,4'-piperidin)-6-ol

: 1355086-06-4
3-{6-((2-chlorophenyl)methoxy)-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-yl}propanoic acid trifluoroacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: diisopropylamine / methanol / Reflux

2: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 16 h / 20 °C

3: water; 1,4-dioxane / 16 h / 50 °C

With di-isopropyl azodicarboxylate; diisopropylamine; triphenylphosphine; In 1,4-dioxane; methanol; dichloromethane; water; 2: |Mitsunobu Displacement;
DOI:10.1016/j.bmcl.2017.12.018

Reference yield:

: 1355088-07-1
tert-butyl 3-[6-hydroxy-2H-spiro(1-benzofuran-3,4'-piperidine)-1'-yl]propanoate

: 1355086-06-4
3-{6-((2-chlorophenyl)methoxy)-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-yl}propanoic acid trifluoroacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 16 h / 20 °C

2: water; 1,4-dioxane / 16 h / 50 °C

With di-isopropyl azodicarboxylate; triphenylphosphine; In 1,4-dioxane; dichloromethane; water; 1: |Mitsunobu Displacement;
DOI:10.1016/j.bmcl.2017.12.018