(1R-trans)-5-bromo-1,2,3,4-tetrahydro-1,3-dimethyl-6,8-bis(phenylmethoxy)-2-(phenylmethyl)isoquinoline

Base Information

Chemical Name:(1R-trans)-5-bromo-1,2,3,4-tetrahydro-1,3-dimethyl-6,8-bis(phenylmethoxy)-2-(phenylmethyl)isoquinoline
CAS No.:160466-01-3
Molecular Formula:C₃₂H₃₂BrNO₂
Molecular Weight:542.516
Hs Code.:

Synonyms:(1R-trans)-5-bromo-1,2,3,4-tetrahydro-1,3-dimethyl-6,8-bis(phenylmethoxy)-2-(phenylmethyl)isoquinoline

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Chemical Property of (1R-trans)-5-bromo-1,2,3,4-tetrahydro-1,3-dimethyl-6,8-bis(phenylmethoxy)-2-(phenylmethyl)isoquinoline

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Technology Process of (1R-trans)-5-bromo-1,2,3,4-tetrahydro-1,3-dimethyl-6,8-bis(phenylmethoxy)-2-(phenylmethyl)isoquinoline

There total 15 articles about (1R-trans)-5-bromo-1,2,3,4-tetrahydro-1,3-dimethyl-6,8-bis(phenylmethoxy)-2-(phenylmethyl)isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 160539-02-6
(1R-trans)-1,2,3,4-tetrahydro-1,3-dimethyl-6,8-bis(phenylmethoxy)-2-phenylmethylisoquinoline

: 160466-01-3
(1R-trans)-5-bromo-1,2,3,4-tetrahydro-1,3-dimethyl-6,8-bis(phenylmethoxy)-2-(phenylmethyl)isoquinoline

Guidance literature:: With bromine; In N,N-dimethyl-formamide; for 72h; Ambient temperature;
DOI:10.3987/COM-94-S(B)79

Reference yield:

: 250212-49-8
(R,R)-N-<1-(3,5-dimethoxyphenyl)-2-propyl>-α-methylbenzenemethanamine

: 160466-01-3
(1R-trans)-5-bromo-1,2,3,4-tetrahydro-1,3-dimethyl-6,8-bis(phenylmethoxy)-2-(phenylmethyl)isoquinoline

Guidance literature:: Multi-step reaction with 6 steps

1.1: 94 percent / Et₃N / CH₂Cl₂ / 20 °C

2.1: POCl₃ / benzene / 5 h / Heating

2.2: 235.5 mg / NaBH₄ / ethanol / 0.5 h / -78 - 20 °C

3.1: H₂ / Pd/C / ethanol / 20 °C / 760 Torr

4.1: 100 percent / BBr₃ / CH₂Cl₂ / 10 h / -78 - 20 °C

5.1: 86 percent / Cs₂CO₃ / dimethylformamide / 6 h / 20 °C

6.1: 71 percent / Br₂ / CH₂Cl₂ / 0.5 h

With hydrogen; bromine; boron tribromide; caesium carbonate; triethylamine; trichlorophosphate; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; benzene; 1.1: Acetylation / 2.1: Bischler-Napieralski reaction / 2.2: Reduction / 3.1: Catalytic hydrogenation / 4.1: Substitution / 5.1: Substitution / 6.1: Bromination;
DOI:10.1021/jo9908187

Reference yield:

: 250212-66-9
[R-(R*,R*)]-[2-(3,5-dimethoxyphenyl)-1-methylethyl]-N-(1-phenylethyl)acetamide

: 160466-01-3
(1R-trans)-5-bromo-1,2,3,4-tetrahydro-1,3-dimethyl-6,8-bis(phenylmethoxy)-2-(phenylmethyl)isoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1.1: POCl₃ / benzene / 5 h / Heating

1.2: 235.5 mg / NaBH₄ / ethanol / 0.5 h / -78 - 20 °C

2.1: H₂ / Pd/C / ethanol / 20 °C / 760 Torr

3.1: 100 percent / BBr₃ / CH₂Cl₂ / 10 h / -78 - 20 °C

4.1: 86 percent / Cs₂CO₃ / dimethylformamide / 6 h / 20 °C

5.1: 71 percent / Br₂ / CH₂Cl₂ / 0.5 h

With hydrogen; bromine; boron tribromide; caesium carbonate; trichlorophosphate; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; benzene; 1.1: Bischler-Napieralski reaction / 1.2: Reduction / 2.1: Catalytic hydrogenation / 3.1: Substitution / 4.1: Substitution / 5.1: Bromination;
DOI:10.1021/jo9908187