Technology Process of (R)-2-[6-(benzyloxy)hexyl]oxirane
There total 3 articles about (R)-2-[6-(benzyloxy)hexyl]oxirane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
8-benzyloxy-1-octanal;
With
2,2,3,4,5,6-hexachloro-cyclohexa-2,4-dien-1-one; (2R,5S)-2-(tert-butyl)-3,5-dimethylimidazolidin-4-one trifluoroacetate;
In
tetrahydrofuran;
at 20 ℃;
for 0.333333h;
Inert atmosphere;
With
sodium tetrahydroborate;
In
tetrahydrofuran; ethanol;
at 0 - 20 ℃;
for 0.25h;
Inert atmosphere;
With
potassium hydroxide;
In
tetrahydrofuran; ethanol; water;
at 20 ℃;
for 0.5h;
enantioselective reaction;
Inert atmosphere;
DOI:10.1021/acs.jmedchem.0c00844
- Guidance literature:
-
With
(S,S)-(salen)cobalt(III)(OAc); water;
at 0 - 20 ℃;
optical yield given as %ee;
DOI:10.1002/ejoc.200800680
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: pyridinium chlorochromate / dichloromethane / Inert atmosphere
2.1: (2R,5S)-2-(tert-butyl)-3,5-dimethylimidazolidin-4-one trifluoroacetate; 2,2,3,4,5,6-hexachloro-cyclohexa-2,4-dien-1-one / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere
2.2: 0.25 h / 0 - 20 °C / Inert atmosphere
2.3: 0.5 h / 20 °C / Inert atmosphere
With
2,2,3,4,5,6-hexachloro-cyclohexa-2,4-dien-1-one; (2R,5S)-2-(tert-butyl)-3,5-dimethylimidazolidin-4-one trifluoroacetate; pyridinium chlorochromate;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/acs.jmedchem.0c00844
