5R,6S-dimethyl-2S-(2'R-propionyl)-1-E/Z-trimethylsilylmethylenecyclohexane

Base Information

Chemical Name:5R,6S-dimethyl-2S-(2'R-propionyl)-1-E/Z-trimethylsilylmethylenecyclohexane
CAS No.:131691-40-2
Molecular Formula:C₁₅H₂₈O₂Si
Molecular Weight:268.472
Hs Code.:

Synonyms:5R,6S-dimethyl-2S-(2'R-propionyl)-1-E/Z-trimethylsilylmethylenecyclohexane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5R,6S-dimethyl-2S-(2'R-propionyl)-1-E/Z-trimethylsilylmethylenecyclohexane

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Technology Process of 5R,6S-dimethyl-2S-(2'R-propionyl)-1-E/Z-trimethylsilylmethylenecyclohexane

There total 7 articles about 5R,6S-dimethyl-2S-(2'R-propionyl)-1-E/Z-trimethylsilylmethylenecyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 131691-38-8
5R,6S-dimethyl-2S-(2'R-propionyl)-1(E/Z)-trimethylsilylmethylenecyclohexane

: 131691-40-2
5R,6S-dimethyl-2S-(2'R-propionyl)-1-E/Z-trimethylsilylmethylenecyclohexane

Guidance literature:: With dipyridinium dichromate; In N,N-dimethyl-formamide;
DOI:10.1039/c39900001487

Reference yield:

: 131691-33-3
(2S,5R)-2-[((R)-2'-tert-butyldimethylsilyloxy)-1'-methylethyl]-5-methylcyclohexan-1-one

: 131691-40-2
5R,6S-dimethyl-2S-(2'R-propionyl)-1-E/Z-trimethylsilylmethylenecyclohexane

Guidance literature:: Multi-step reaction with 4 steps

1: 58 percent / lithium diisopropylamide / tetrahydrofuran; hexane / 0.42 h / Ambient temperature

2: 41 percent / t-butyllithium / pentane / Ambient temperature

3: 88 percent / Bu₄NF / tetrahydrofuran / 2.5 h / 22 °C

4: 79 percent / pyridinium dichromate / dimethylformamide / 18 h / Ambient temperature

With dipyridinium dichromate; tetrabutyl ammonium fluoride; tert.-butyl lithium; lithium diisopropyl amide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; pentane;
DOI:10.1016/S0040-4020(01)80810-3

Reference yield:

: 13834-07-6
(1R,3R,4S,8R)-9-hydroxy-p-menthol

: 131691-40-2
5R,6S-dimethyl-2S-(2'R-propionyl)-1-E/Z-trimethylsilylmethylenecyclohexane

Guidance literature:: Multi-step reaction with 6 steps

1: 83 percent / 4-N,N'-dimethylaminopyridine, triethylamine / CH₂Cl₂ / 18 h / Ambient temperature

2: 87 percent / dimethylsulfoxide, oxalyl chloride / CH₂Cl₂ / 1 h / -78 °C

3: 58 percent / lithium diisopropylamide / tetrahydrofuran; hexane / 0.42 h / Ambient temperature

4: 41 percent / t-butyllithium / pentane / Ambient temperature

5: 88 percent / Bu₄NF / tetrahydrofuran / 2.5 h / 22 °C

6: 79 percent / pyridinium dichromate / dimethylformamide / 18 h / Ambient temperature

With dmap; dipyridinium dichromate; oxalyl dichloride; tetrabutyl ammonium fluoride; tert.-butyl lithium; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; pentane;
DOI:10.1016/S0040-4020(01)80810-3