N-{5-[(S)-2-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-butyl]-2-methoxy-benzyl}-2-fluoro-4-trifluoromethyl-benzamide

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Chemical Name:N-{5-[(S)-2-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-butyl]-2-methoxy-benzyl}-2-fluoro-4-trifluoromethyl-benzamide
CAS No.:878268-51-0
Molecular Formula:C₃₁H₃₀F₄N₂O₅
Molecular Weight:586.583
Hs Code.:

Synonyms:N-{5-[(S)-2-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-butyl]-2-methoxy-benzyl}-2-fluoro-4-trifluoromethyl-benzamide

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Chemical Property of N-{5-[(S)-2-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-butyl]-2-methoxy-benzyl}-2-fluoro-4-trifluoromethyl-benzamide

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Technology Process of N-{5-[(S)-2-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-butyl]-2-methoxy-benzyl}-2-fluoro-4-trifluoromethyl-benzamide

There total 4 articles about N-{5-[(S)-2-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-butyl]-2-methoxy-benzyl}-2-fluoro-4-trifluoromethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 207853-64-3
2-fluoro-4-trifluoromethyl benzoic acid amide

: 878268-53-2
5-[(S)-2-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-butyl]-2-methoxy-benzaldehyde

: 878268-51-0
N-{5-[(S)-2-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-butyl]-2-methoxy-benzyl}-2-fluoro-4-trifluoromethyl-benzamide

Guidance literature:: With triethylsilane; trifluoroacetic acid; In toluene; for 24h; Heating;
DOI:10.1016/j.bmcl.2005.11.029

Reference yield: 15.0%

: 207853-64-3
2-fluoro-4-trifluoromethyl benzoic acid amide

: (S)-4-Benzyl-3-[(S)-2-(3-bromomethyl-4-methoxy-benzyl)-butyryl]-oxazolidin-2-one

: 878268-51-0
N-{5-[(S)-2-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-butyl]-2-methoxy-benzyl}-2-fluoro-4-trifluoromethyl-benzamide

Guidance literature:: (S)-4-Benzyl-3-[(S)-2-(3-bromomethyl-4-methoxy-benzyl)-butyryl]-oxazolidin-2-one; With sodium hydride; In tetrahydrofuran; at 0 ℃;

2-fluoro-4-trifluoromethyl benzoic acid amide; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmcl.2005.11.029

Reference yield:

: 878268-36-1
(S)-4-Benzyl-3-[(S)-2-(3-hydroxymethyl-4-methoxy-benzyl)-butyryl]-oxazolidin-2-one

: 878268-51-0
N-{5-[(S)-2-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-butyl]-2-methoxy-benzyl}-2-fluoro-4-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / MnO₂ / CH₂Cl₂ / 20 °C

2: 66 percent / triethylsilane; trifluoroacetic acid / toluene / 24 h / Heating

With triethylsilane; manganese(IV) oxide; trifluoroacetic acid; In dichloromethane; toluene;
DOI:10.1016/j.bmcl.2005.11.029