3-{2-[5-methyl-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-acetylaminobenzoic acid

Base Information

Chemical Name:3-{2-[5-methyl-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-acetylaminobenzoic acid
CAS No.:632624-91-0
Molecular Formula:C₂₈H₂₅FN₂O₄
Molecular Weight:472.516
Hs Code.:

Synonyms:3-{2-[5-methyl-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-acetylaminobenzoic acid

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Chemical Property of 3-{2-[5-methyl-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-acetylaminobenzoic acid

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Technology Process of 3-{2-[5-methyl-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-acetylaminobenzoic acid

There total 4 articles about 3-{2-[5-methyl-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-acetylaminobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 632627-76-0
1-[5-methyl-2-(4-fluorobenzyloxy)phenyl]-pentane-1,4-dione

: 15089-84-6
3-acetylamino-5-aminobenzoic acid

: 632624-91-0
3-{2-[5-methyl-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-acetylaminobenzoic acid

Guidance literature:: toluene-4-sulfonic acid; In 1-methyl-pyrrolidin-2-one; at 150 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 632627-75-9
5-methyl-2-(4-fluorobenzyloxy)benzaldehyde

: 632624-91-0
3-{2-[5-methyl-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-acetylaminobenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine / ethanol / 5 h / Heating / reflux

2: toluene-4-sulfonic acid / 1-methyl-pyrrolidin-2-one / 0.17 h / 150 °C / Microwave irradiation

With 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine; toluene-4-sulfonic acid; In 1-methyl-pyrrolidin-2-one; ethanol;

Reference yield:

: 613-84-3
2-hydroxy-5-methylbenzaldehyde

: 632624-91-0
3-{2-[5-methyl-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-acetylaminobenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 1.75 h / Heating / reflux

2: 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine / ethanol / 5 h / Heating / reflux

3: toluene-4-sulfonic acid / 1-methyl-pyrrolidin-2-one / 0.17 h / 150 °C / Microwave irradiation

With 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; potassium carbonate; triethylamine; toluene-4-sulfonic acid; In 1-methyl-pyrrolidin-2-one; ethanol; acetone;