7-(5-Phenyl-Δ²-isoxazolin-3-yl)-6-methyl-2,4-diphenyl-2,3,4-trihydrothiazolo<3,2-a>-s-triazine

Base Information

• Chemical Name: 7-(5-Phenyl-Δ²-isoxazolin-3-yl)-6-methyl-2,4-diphenyl-2,3,4-trihydrothiazolo<3,2-a>-s-triazine
• CAS No.: 87102-48-5
• Molecular Formula: C₂₇H₂₄N₄OS
• Molecular Weight: 452.58

Synonyms:7-(5-Phenyl-Δ²-isoxazolin-3-yl)-6-methyl-2,4-diphenyl-2,3,4-trihydrothiazolo<3,2-a>-s-triazine

Chemical Property of 7-(5-Phenyl-Δ²-isoxazolin-3-yl)-6-methyl-2,4-diphenyl-2,3,4-trihydrothiazolo<3,2-a>-s-triazine

Chemical Property:

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Technology Process of 7-(5-Phenyl-Δ²-isoxazolin-3-yl)-6-methyl-2,4-diphenyl-2,3,4-trihydrothiazolo<3,2-a>-s-triazine

There total 5 articles about 7-(5-Phenyl-Δ²-isoxazolin-3-yl)-6-methyl-2,4-diphenyl-2,3,4-trihydrothiazolo<3,2-a>-s-triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(E)-1-(6-Methyl-2,4-diphenyl-3,4-dihydro-2H-thiazolo[3,2-a][1,3,5]triazin-7-yl)-3-phenyl-propenone (87102-39-4) → 7-(5-Phenyl-Δ2-isoxazolin-3-yl)-6-methyl-2,4-diphenyl-2,3,4-trihydrothiazolo<3,2-a>-s-triazine (87102-48-5)

Guidance literature:

With sodium hydroxide; hydroxylamine hydrochloride; In 1,4-dioxane; for 6h; Heating;

DOI:10.1021/je00035a032

Reference yield:

4,6-diphenyl[1,3,5]triazinane-2-thione (61582-10-3) → 7-(5-Phenyl-Δ2-isoxazolin-3-yl)-6-methyl-2,4-diphenyl-2,3,4-trihydrothiazolo<3,2-a>-s-triazine (87102-48-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 70 percent / 1.) 85percent KOH / ethanol / 1.) 70-80 deg C, 10 min, 2.) room temp., 18 h

2: 60 percent / polyphosphoric acid / 1.) 100 deg C, 1 h, 2.) 120 deg C, 15 min

3: 70 percent / piperidine / 0.5 h / 160 °C

4: 72 percent / hydroxylamine hydrochloride, NaOH / dioxane / 6 h / Heating

With piperidine; potassium hydroxide; sodium hydroxide; PPA; hydroxylamine hydrochloride; In 1,4-dioxane; ethanol;

DOI:10.1021/je00035a032

Reference yield:

(E)-3-(4,6-Diphenyl-1,4,5,6-tetrahydro-[1,3,5]triazin-2-ylsulfanyl)-4-hydroxy-pent-3-en-2-one (87102-24-7) → 7-(5-Phenyl-Δ2-isoxazolin-3-yl)-6-methyl-2,4-diphenyl-2,3,4-trihydrothiazolo<3,2-a>-s-triazine (87102-48-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 60 percent / polyphosphoric acid / 1.) 100 deg C, 1 h, 2.) 120 deg C, 15 min

2: 70 percent / piperidine / 0.5 h / 160 °C

3: 72 percent / hydroxylamine hydrochloride, NaOH / dioxane / 6 h / Heating

With piperidine; sodium hydroxide; PPA; hydroxylamine hydrochloride; In 1,4-dioxane;

DOI:10.1021/je00035a032

upstream raw materials:

(E)-1-(6-Methyl-2,4-diphenyl-3,4-dihydro-2H-thiazolo[3,2-a][1,3,5]triazin-7-yl)-3-phenyl-propenone

4,6-diphenyl[1,3,5]triazinane-2-thione

(E)-3-(4,6-Diphenyl-1,4,5,6-tetrahydro-[1,3,5]triazin-2-ylsulfanyl)-4-hydroxy-pent-3-en-2-one

1-(6-Methyl-2,4-diphenyl-3,4-dihydro-2H-thiazolo[3,2-a][1,3,5]triazin-7-yl)-ethanone

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