2-(4-methoxyphenyl)-3-p-tolylquinoxaline

Base Information

• Chemical Name: 2-(4-methoxyphenyl)-3-p-tolylquinoxaline
• CAS No.: 1266239-30-8
• Molecular Formula: C₂₂H₁₈N₂O
• Molecular Weight: 326.398
• Mol file: 1266239-30-8.mol

Synonyms:2-(4-methoxyphenyl)-3-p-tolylquinoxaline

Chemical Property of 2-(4-methoxyphenyl)-3-p-tolylquinoxaline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-methoxyphenyl)-3-p-tolylquinoxaline

There total 4 articles about 2-(4-methoxyphenyl)-3-p-tolylquinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-methoxy-4-[2-(4-methylphenyl)ethynyl]benzene (24785-38-4) + 1,2-diamino-benzene (95-54-5) → 2-(4-methoxyphenyl)-3-p-tolylquinoxaline (1266239-30-8)

Guidance literature:

1-methoxy-4-[2-(4-methylphenyl)ethynyl]benzene; With iodine; In dimethyl sulfoxide; at 130 ℃; for 10h;

1,2-diamino-benzene; In dimethyl sulfoxide; at 20 ℃; for 1h;

DOI:10.1080/00397911.2018.1428752

Reference yield: 75.0%

1-(4-methoxyphenyl)-2-(4-methylphenyl)ethane-1,2-dione (33425-19-3) + 1,2-diamino-benzene (95-54-5) → 2-(4-methoxyphenyl)-3-p-tolylquinoxaline (1266239-30-8)

Guidance literature:

With acetic acid; at 60 ℃; for 2h;

DOI:10.1002/ejoc.201001232

Reference yield:

4-methylphenylacetyl chloride (35675-44-6) → 2-(4-methoxyphenyl)-3-p-tolylquinoxaline (1266239-30-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum (III) chloride / dichloromethane / 0 - 20 °C

2: copper(II) acetate monohydrate; potassium carbonate; oxygen / N,N-dimethyl-formamide / 5 h / 90 °C / 760.05 Torr

With aluminum (III) chloride; oxygen; copper(II) acetate monohydrate; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2015.02.019

upstream raw materials:

1-(4-methoxyphenyl)-2-(4-methylphenyl)ethane-1,2-dione

1,2-diamino-benzene

4-methylphenylacetyl chloride

4-tolylacetic acid