2'-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-[2,4']bioxazolyl-4-carbaldehyde

Base Information

Chemical Name:2'-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-[2,4']bioxazolyl-4-carbaldehyde
CAS No.:233750-48-6
Molecular Formula:C₂₆H₂₈N₂O₄Si
Molecular Weight:460.605
Hs Code.:

2'-[3-(<i>tert</i>-butyl-diphenyl-silanyloxy)-propyl]-[2,4']bioxazolyl-4-carbaldehyde

Synonyms:2'-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-[2,4']bioxazolyl-4-carbaldehyde

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Chemical Property of 2'-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-[2,4']bioxazolyl-4-carbaldehyde

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Technology Process of 2'-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-[2,4']bioxazolyl-4-carbaldehyde

There total 14 articles about 2'-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-[2,4']bioxazolyl-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 233750-52-2
2'-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-[2,4']bioxazolyl-4-carboxylic acid methyl ester

: 233750-48-6
2'-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-[2,4']bioxazolyl-4-carbaldehyde

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at -78 ℃;
DOI:10.1021/ja9904686

Reference yield: 71.0%

: 853406-74-3
2'-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-[2,4']bioxazolyl-4-carboxylic acid ethyl ester

: 233750-48-6
2'-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-[2,4']bioxazolyl-4-carbaldehyde

Guidance literature:: With diisobutylaluminium hydride; In hexane; dichloromethane; at -78 ℃; for 0.25h;
DOI:10.1021/ol050543j

Reference yield:

: 233750-78-2
2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-oxazole-4-carboxylic acid

: 233750-48-6
2'-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-[2,4']bioxazolyl-4-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 280 mg / DPPA; Et₃N / dimethylformamide / 0 - 20 °C

2: 75 percent / (NH₄)2MoO₄ / chlorobenzene / 20 h / Heating

3: 69 percent / BrCCl₃; DBU / CH₂Cl₂ / 2 h / 0 °C

4: 71 percent / DIBAL / CH₂Cl₂; hexane / 0.25 h / -78 °C

With ammonium molibdate; Bromotrichloromethane; diphenyl-phosphinic acid; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In hexane; dichloromethane; N,N-dimethyl-formamide; chlorobenzene;
DOI:10.1021/ol050543j