3-amino-N¹-benzylidene-6-(2-thienyl)-4-trifluoromethylthieno[2,3-b]pyridine-2-carbohydrazide

Base Information

• Chemical Name: 3-amino-N¹-benzylidene-6-(2-thienyl)-4-trifluoromethylthieno[2,3-b]pyridine-2-carbohydrazide
• CAS No.: 883555-39-3
• Molecular Formula: C₂₀H₁₃F₃N₄OS₂
• Molecular Weight: 446.477

Synonyms:3-amino-N¹-benzylidene-6-(2-thienyl)-4-trifluoromethylthieno[2,3-b]pyridine-2-carbohydrazide

Chemical Property of 3-amino-N¹-benzylidene-6-(2-thienyl)-4-trifluoromethylthieno[2,3-b]pyridine-2-carbohydrazide

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Technology Process of 3-amino-N¹-benzylidene-6-(2-thienyl)-4-trifluoromethylthieno[2,3-b]pyridine-2-carbohydrazide

There total 6 articles about 3-amino-N¹-benzylidene-6-(2-thienyl)-4-trifluoromethylthieno[2,3-b]pyridine-2-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N1-benzylidene-[3-cyano-6-(2-thienyl)-4-trifluoromethylpyridin-2-ylthio]acetohydrazide (883555-34-8) → 3-amino-N1-benzylidene-6-(2-thienyl)-4-trifluoromethylthieno[2,3-b]pyridine-2-carbohydrazide (883555-39-3)

Guidance literature:

With sodium acetate; In ethanol; for 4h; Heating;

Reference yield:

4-(trifluoromethyl)-1,2-dihydro-6-(thiophen-2-yl)-2-thioxopyridine-3-carbonitrile (104960-50-1) → 3-amino-N1-benzylidene-6-(2-thienyl)-4-trifluoromethylthieno[2,3-b]pyridine-2-carbohydrazide (883555-39-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 80 percent / sodium acetate trihydrate / ethanol / 0.17 h / Heating

2: 47 percent / hydrazine hydrate / ethanol / 0.17 h / Heating

3: 89 percent / ethanol / 2 h / Heating

4: 92 percent / sodium acetate trihydrate / ethanol / 4 h / Heating

With sodium acetate; hydrazine hydrate; In ethanol; 4: Thorpe-Ziegler cyclisation;

Reference yield:

ethyl 2-(3-cyano-4-(trifluoromethyl)-6-(thiophen-2-yl)pyridine-2-ylthio)acetate (299198-22-4) → 3-amino-N1-benzylidene-6-(2-thienyl)-4-trifluoromethylthieno[2,3-b]pyridine-2-carbohydrazide (883555-39-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 47 percent / hydrazine hydrate / ethanol / 0.17 h / Heating

2: 89 percent / ethanol / 2 h / Heating

3: 92 percent / sodium acetate trihydrate / ethanol / 4 h / Heating

With sodium acetate; hydrazine hydrate; In ethanol; 3: Thorpe-Ziegler cyclisation;

upstream raw materials:

N¹-benzylidene-[3-cyano-6-(2-thienyl)-4-trifluoromethylpyridin-2-ylthio]acetohydrazide

3-amino-6-(thiophen-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxylic acid hydrazide

benzaldehyde

ethyl 2-(3-cyano-4-(trifluoromethyl)-6-(thiophen-2-yl)pyridine-2-ylthio)acetate

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