methyl 6-iodo-5-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxylate

Base Information

Chemical Name:methyl 6-iodo-5-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxylate
CAS No.:956907-50-9
Molecular Formula:C₁₄H₁₀F₃IN₂O₃
Molecular Weight:438.145
Hs Code.:

Synonyms:methyl 6-iodo-5-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxylate

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Chemical Property of methyl 6-iodo-5-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxylate

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Technology Process of methyl 6-iodo-5-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxylate

There total 7 articles about methyl 6-iodo-5-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 956907-37-2
5-Methyl-3-oxo-4-(3-trifluoromethyl-phenyl)-3,4-dihydro-pyrazine-2-carboxylic acid methyl ester

: 956907-50-9
methyl 6-iodo-5-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxylate

Guidance literature:: With N-iodo-succinimide; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 5h;

Reference yield:

: 956907-59-8
3-bromo-6-methyl-1-[3-(trifluoromethyl)phenyl]pyrazin-2(1H)-one

: 956907-50-9
methyl 6-iodo-5-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / palladium diacetate; triphenylphosphine / 4 h / 90 °C / 4560.31 Torr

2: N-iodo-succinimide; trifluoroacetic acid / dichloromethane / 5 h / 20 °C / in the dark

With N-iodo-succinimide; triethylamine; trifluoroacetic acid; palladium diacetate; triphenylphosphine; In dichloromethane;

Reference yield:

: 433241-66-8
N-(2-hydroxypropyl)-N'-[3-(trifluoromethyl)-phenyl]ethanediamide

: 956907-50-9
methyl 6-iodo-5-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium bromate / ruthenium trichloride / water; acetonitrile / 1 h

2.1: sulfuric acid / acetic acid / 3 h / 100 °C / Sealed vial

2.2: pH 6 - 7

3.1: Oxalyl bromide / N,N-dimethyl-formamide / 1,2-dichloro-ethane / sealed vial

4.1: triethylamine / palladium diacetate; triphenylphosphine / 4 h / 90 °C / 4560.31 Torr

5.1: N-iodo-succinimide; trifluoroacetic acid / dichloromethane / 5 h / 20 °C / in the dark

With sodium bromate; N-iodo-succinimide; Oxalyl bromide; triethylamine; trifluoroacetic acid; ruthenium trichloride; palladium diacetate; sulfuric acid; N,N-dimethyl-formamide; triphenylphosphine; In dichloromethane; water; acetic acid; 1,2-dichloro-ethane; acetonitrile;