trans-3-methoxy-5-(6,7,8-trimethoxy-2,3-dimethyl-1,2-dihydronaphthalen-1-yl)benzene-1,2-diol

Base Information

• Chemical Name: trans-3-methoxy-5-(6,7,8-trimethoxy-2,3-dimethyl-1,2-dihydronaphthalen-1-yl)benzene-1,2-diol
• CAS No.: 142501-55-1
• Molecular Formula: C₂₂H₂₆O₆
• Molecular Weight: 386.445
• Mol file: 142501-55-1.mol

Synonyms:trans-3-methoxy-5-(6,7,8-trimethoxy-2,3-dimethyl-1,2-dihydronaphthalen-1-yl)benzene-1,2-diol

Chemical Property of trans-3-methoxy-5-(6,7,8-trimethoxy-2,3-dimethyl-1,2-dihydronaphthalen-1-yl)benzene-1,2-diol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-3-methoxy-5-(6,7,8-trimethoxy-2,3-dimethyl-1,2-dihydronaphthalen-1-yl)benzene-1,2-diol

There total 3 articles about trans-3-methoxy-5-(6,7,8-trimethoxy-2,3-dimethyl-1,2-dihydronaphthalen-1-yl)benzene-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

Isobutyric acid (1R,2S)-3-(5-methoxy-3,4-dioxo-cyclohexa-1,5-dienyl)-1,2-dimethyl-1-(3,4,5-trimethoxy-benzyl)-propyl ester → trans-3-methoxy-5-(6,7,8-trimethoxy-2,3-dimethyl-1,2-dihydronaphthalen-1-yl)benzene-1,2-diol (142501-55-1)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; for 3h; Ambient temperature;

DOI:10.1248/cpb.44.909

Reference yield: 8.0%

Isobutyric acid (1R,2S)-3-(5-methoxy-3,4-dioxo-cyclohexa-1,5-dienyl)-1,2-dimethyl-1-(3,4,5-trimethoxy-benzyl)-propyl ester → trans-3-methoxy-5-(6,7,8-trimethoxy-2,3-dimethyl-1,2-dihydronaphthalen-1-yl)benzene-1,2-diol (142501-55-1) + Isobutyric acid (2S,3R,4S)-4-(3,4-dihydroxy-5-methoxy-phenyl)-5,6,7-trimethoxy-2,3-dimethyl-1,2,3,4-tetrahydro-naphthalen-2-yl ester

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at -78 ℃; for 2h;

DOI:10.1248/cpb.44.909

Reference yield:

(1RS,2RS,3SR)-4-(4-hydroxy-3,5-dimethoxyphenyl)-2,3-dimethyl-1-(3,4,5-trimethoxyphenyl)butyl acetate (142501-54-0) → trans-3-methoxy-5-(6,7,8-trimethoxy-2,3-dimethyl-1,2-dihydronaphthalen-1-yl)benzene-1,2-diol (142501-55-1) + trans-2,6-dimethoxy-4-(6,7,8-trimethoxy-2,3-dimethyl-1,2-dihydronaphthalen-1-yl)phenol (142501-44-8)

Guidance literature:

With sodium disulfite; potassium iodide; thallium(III) trifluoroacetate; Yield given. Multistep reaction. Yields of byproduct given;

upstream raw materials:

(1RS,2RS,3SR)-4-(4-hydroxy-3,5-dimethoxyphenyl)-2,3-dimethyl-1-(3,4,5-trimethoxyphenyl)butyl acetate

Downstream raw materials:

trans-6,7,8-trimethoxy-2,3-dimethyl-1-(3,4,5-timethoxyphenyl)-1,2-dihydronaphthalene