Technology Process of 4-(3,3-dimethyl-4-oxo-cyclopentyl)-3-fluoro-benzonitrile
There total 3 articles about 4-(3,3-dimethyl-4-oxo-cyclopentyl)-3-fluoro-benzonitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
zinc(II) cyanide; 4-(4-chloro-2-fluoro-phenyl)-2,2-dimethyl-cyclopentanone;
With
4-[4-hydroxy-1-(p-tolylsulfonyl)-6,7-dihydro-5H-indazol-4-yl]benzonitrile;
In
1-methyl-pyrrolidin-2-one;
at 125 ℃;
for 0.25h;
bis(η3-allyl-μ-chloropalladium(II));
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate; allyl diethyl phosphate / palladium diacetate / tert-Amyl alcohol / 12 h / 80 °C
2.1: sodium acetate; acetic acid; antimony(III) chloride / palladium diacetate / 16 h / 20 °C
3.1: 4-[4-hydroxy-1-(p-tolylsulfonyl)-6,7-dihydro-5H-indazol-4-yl]benzonitrile / 1-methyl-pyrrolidin-2-one / 0.25 h / 125 °C
3.2: 0.5 h
With
allyl diethyl phosphate; 4-[4-hydroxy-1-(p-tolylsulfonyl)-6,7-dihydro-5H-indazol-4-yl]benzonitrile; sodium acetate; antimony(III) chloride; potassium carbonate; acetic acid;
palladium diacetate;
In
1-methyl-pyrrolidin-2-one; tert-Amyl alcohol;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium acetate; acetic acid; antimony(III) chloride / palladium diacetate / 16 h / 20 °C
2.1: 4-[4-hydroxy-1-(p-tolylsulfonyl)-6,7-dihydro-5H-indazol-4-yl]benzonitrile / 1-methyl-pyrrolidin-2-one / 0.25 h / 125 °C
2.2: 0.5 h
With
4-[4-hydroxy-1-(p-tolylsulfonyl)-6,7-dihydro-5H-indazol-4-yl]benzonitrile; sodium acetate; antimony(III) chloride; acetic acid;
palladium diacetate;
In
1-methyl-pyrrolidin-2-one;
