cyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodophenylamino)-benzooxazol-7-yl]amide

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Chemical Name:cyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodophenylamino)-benzooxazol-7-yl]amide
CAS No.:1311400-85-7
Molecular Formula:C₁₆H₁₁F₃IN₃O₃S
Molecular Weight:509.247
Hs Code.:

Synonyms:cyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodophenylamino)-benzooxazol-7-yl]amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of cyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodophenylamino)-benzooxazol-7-yl]amide

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Technology Process of cyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodophenylamino)-benzooxazol-7-yl]amide

There total 11 articles about cyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodophenylamino)-benzooxazol-7-yl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.5%

: 1311401-48-5
8-cyclopropanesulfonyl-4,5-difluoro-6-(2-fluoro-4-iodophenyl)-6,8-dihydroimidazo[4',5':3,4]benzo[1,2-d]oxazol-7-one

: 1311400-85-7
cyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodophenylamino)-benzooxazol-7-yl]amide

Guidance literature:: With potassium trimethylsilonate; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 29632-74-4
2-fluro-4-iodoaniline

: 1311400-85-7
cyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodophenylamino)-benzooxazol-7-yl]amide

Guidance literature:: Multi-step reaction with 10 steps

1.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / 1 h / -78 °C

1.2: 1 h / 20 °C

2.1: tetrahydrofuran / -78 - 20 °C

3.1: hydrogenchloride / water; tetrahydrofuran / 0.08 h

3.2: 20 °C

4.1: dichloromethane / 20 °C

5.1: nitric acid / 0.1 h / -78 - 20 °C

5.2: Cooling

6.1: hydrogenchloride / water; tetrahydrofuran / 0.08 h

6.2: 20 °C

7.1: boron tribromide / dichloromethane / 0 - 20 °C

7.2: 1 h

8.1: toluene-4-sulfonic acid / 0.5 h / 120 °C

9.1: dmap; triethylamine / dichloromethane / 0.25 h / 0 °C

9.2: 3 h / 20 °C

10.1: potassium trimethylsilonate / tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; dmap; potassium trimethylsilonate; nitric acid; boron tribromide; toluene-4-sulfonic acid; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane; water;

Reference yield:

: 923032-72-8
(2,3-difluoro-5-methoxy-6-nitro-phenyl)-(2-fluoro-4-iodo-phenyl)-amine

: 1311400-85-7
cyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodophenylamino)-benzooxazol-7-yl]amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride / water; tetrahydrofuran / 0.08 h

1.2: 20 °C

2.1: dichloromethane / 20 °C

3.1: nitric acid / 0.1 h / -78 - 20 °C

3.2: Cooling

4.1: hydrogenchloride / water; tetrahydrofuran / 0.08 h

4.2: 20 °C

5.1: boron tribromide / dichloromethane / 0 - 20 °C

5.2: 1 h

6.1: toluene-4-sulfonic acid / 0.5 h / 120 °C

7.1: dmap; triethylamine / dichloromethane / 0.25 h / 0 °C

7.2: 3 h / 20 °C

8.1: potassium trimethylsilonate / tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; dmap; potassium trimethylsilonate; nitric acid; boron tribromide; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; dichloromethane; water;