2-amino-5-methylhexanoic acid hydrochloride

Base Information

• Chemical Name: 2-amino-5-methylhexanoic acid hydrochloride
• CAS No.: 57224-44-9
• Molecular Formula: C₇H₁₅NO₂*ClH
• Molecular Weight: 181.663
• Mol file: 57224-44-9.mol

Synonyms:2-amino-5-methylhexanoic acid hydrochloride

Chemical Property of 2-amino-5-methylhexanoic acid hydrochloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-5-methylhexanoic acid hydrochloride

There total 4 articles about 2-amino-5-methylhexanoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl 2-acetamido-5-methylhexanoate → 2-amino-5-methylhexanoic acid hydrochloride (57224-44-9,1330286-49-1)

Guidance literature:

With hydrogenchloride; In water; at 100 ℃; for 6h;

DOI:10.1021/jacs.8b05283

Reference yield:

prenyl bromide (870-63-3) → 2-amino-5-methylhexanoic acid hydrochloride (57224-44-9,1330286-49-1)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 55 °C

2: palladium on activated charcoal; hydrogen / methanol

3: lithium bromide; water / N,N-dimethyl-formamide / 140 °C

4: hydrogenchloride / water / 6 h / 100 °C

With hydrogenchloride; palladium on activated charcoal; water; hydrogen; potassium carbonate; lithium bromide; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jacs.8b05283

Reference yield:

diethyl 2-acetamido-2-isopentylmalonate → 2-amino-5-methylhexanoic acid hydrochloride (57224-44-9,1330286-49-1)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium bromide; water / N,N-dimethyl-formamide / 140 °C

2: hydrogenchloride / water / 6 h / 100 °C

With hydrogenchloride; water; lithium bromide; In water; N,N-dimethyl-formamide;

DOI:10.1021/jacs.8b05283

upstream raw materials:

prenyl bromide

diethyl 2-acetamido-2-(3-methylbut-2-en-1-yl)malonate

Downstream raw materials:

L-2-amino-5-methyl hexanoic acid