(3aR-(3aα,4β,7β,7aα))-3a,4,5,6,7,7a-Hexahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2(3H)-on

Base Information

• Chemical Name: (3aR-(3aα,4β,7β,7aα))-3a,4,5,6,7,7a-Hexahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2(3H)-on
• CAS No.: 81969-33-7
• Molecular Formula: C₁₂H₁₈O₂
• Molecular Weight: 194.274
• Mol file: 81969-33-7.mol

Synonyms:(3aR-(3aα,4β,7β,7aα))-3a,4,5,6,7,7a-Hexahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2(3H)-on

Chemical Property of (3aR-(3aα,4β,7β,7aα))-3a,4,5,6,7,7a-Hexahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2(3H)-on

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3aR-(3aα,4β,7β,7aα))-3a,4,5,6,7,7a-Hexahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2(3H)-on

There total 2 articles about (3aR-(3aα,4β,7β,7aα))-3a,4,5,6,7,7a-Hexahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2(3H)-on which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

[(1S,3R,4R)-3-Hydroxy-4,7,7-trimethyl-bicyclo[2.2.1]hept-(2E)-ylidene]-acetic acid (178969-81-8) → <1R-(endo,exo)>-3-Hydroxy-4,7,7-trimethylbicyclo<2.2.1>heptan-2-essigsaeure (81925-04-4) + (3aR-(3aα,4β,7β,7aα))-3a,4,5,6,7,7a-Hexahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2(3H)-on (81969-33-7)

Guidance literature:

With sodium hydroxide; hydrogen; palladium on activated charcoal; for 3h; under 3000.2 Torr;

Reference yield:

(1R)-4,7,7-Trimethyl-3-oxobicyclo<2.2.1>heptane-2-acetic acid (137492-10-5) → <1R-(endo,exo)>-3-Hydroxy-4,7,7-trimethylbicyclo<2.2.1>heptan-2-essigsaeure (81925-04-4) + (3aR-(3aα,4β,7β,7aα))-3a,4,5,6,7,7a-Hexahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2(3H)-on (81969-33-7) + <3aS-(3aα,4α,7α,7aα)>-3a,4,5,6,7,7a-Hexahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2(3H)-on (81969-31-5)

Guidance literature:

With sodium tetrahydroborate; Yield given. Yields of byproduct given;

Reference yield: 80.0%

(3aR-(3aα,4β,7β,7aα))-3a,4,5,6,7,7a-Hexahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2(3H)-on (81969-33-7) → (2S,2'S-(2α,2'α,3aα,3a'α,4β,4'β,7β,7'β,7aα,7a'α))-2,2'-oxybis[octahydro-7,8,8-trimethyl-4,7-methanobenzofuran] (108031-80-7)

Guidance literature:

With diisobutylaluminium hydride; In hexane; toluene; at -20 ℃; for 1h;

upstream raw materials:

(1R)-4,7,7-Trimethyl-3-oxobicyclo<2.2.1>heptane-2-acetic acid

[(1S,3R,4R)-3-Hydroxy-4,7,7-trimethyl-bicyclo[2.2.1]hept-(2E)-ylidene]-acetic acid

Downstream raw materials:

(2S,2'S-(2α,2'α,3aα,3a'α,4β,4'β,7β,7'β,7aα,7a'α))-2,2'-oxybis[octahydro-7,8,8-trimethyl-4,7-methanobenzofuran]

((S)-1-Phenyl-ethyl)-((1R,2R,4R,6R,7R)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.0^2,6]dec-4-yl)-amine; hydrochloride

((S)-1-Phenyl-ethyl)-((1R,2R,4S,6R,7R)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.0^2,6]dec-4-yl)-amine

<2R-(2a(S*),3aα,4β,7β.7aα)>-N-(Octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)benzoethanamin