4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-(S)-methoxybutyric acid

Base Information

Chemical Name:4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-(S)-methoxybutyric acid
CAS No.:1455088-93-3
Molecular Formula:C₂₂H₁₉N₃O₆
Molecular Weight:421.409
Hs Code.:

Synonyms:4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-(S)-methoxybutyric acid

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Chemical Property of 4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-(S)-methoxybutyric acid

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Technology Process of 4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-(S)-methoxybutyric acid

There total 4 articles about 4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-(S)-methoxybutyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1455093-50-1
4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-(S)-methoxybutyric acid methyl ester

: 1455088-93-3
4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-(S)-methoxybutyric acid

Guidance literature:: With sodium hydroxide; In water; N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: 1455088-71-7
(S)-4-(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carboxamido)-2-hydroxybutanoic acid

: 1455088-93-3
4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-(S)-methoxybutyric acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.05 h / 0 °C

2.2: 0 - 20 °C

3.1: sodium hydroxide / N,N-dimethyl-formamide; water / 4 h / 20 °C

With thionyl chloride; sodium hydride; sodium hydroxide; In water; N,N-dimethyl-formamide;

Reference yield:

: 1455129-05-1
(S)-methyl 4-(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carboxamido)-2-hydroxybutanoate

: 1455088-93-3
4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-(S)-methoxybutyric acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.05 h / 0 °C

1.2: 0 - 20 °C

2.1: sodium hydroxide / N,N-dimethyl-formamide; water / 4 h / 20 °C

With sodium hydride; sodium hydroxide; In water; N,N-dimethyl-formamide;