(diethoxy-phosphoryl)-(2-[1,3]dioxolan-2-yl-phenyl)-acetic acid methyl ester

Base Information

Chemical Name:(diethoxy-phosphoryl)-(2-[1,3]dioxolan-2-yl-phenyl)-acetic acid methyl ester
CAS No.:935680-00-5
Molecular Formula:C₁₆H₂₃O₇P
Molecular Weight:358.328
Hs Code.:

Synonyms:(diethoxy-phosphoryl)-(2-[1,3]dioxolan-2-yl-phenyl)-acetic acid methyl ester

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Chemical Property of (diethoxy-phosphoryl)-(2-[1,3]dioxolan-2-yl-phenyl)-acetic acid methyl ester

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Technology Process of (diethoxy-phosphoryl)-(2-[1,3]dioxolan-2-yl-phenyl)-acetic acid methyl ester

There total 1 articles about (diethoxy-phosphoryl)-(2-[1,3]dioxolan-2-yl-phenyl)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1067-74-9
Methyl diethylphosphonoacetate

: 152302-84-6
2-iodobenzaldehyde ethylene glycol ketal

: 935680-00-5
(diethoxy-phosphoryl)-(2-[1,3]dioxolan-2-yl-phenyl)-acetic acid methyl ester

Guidance literature:: Methyl diethylphosphonoacetate; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

2-iodobenzaldehyde ethylene glycol ketal; With copper(l) iodide; In N,N-dimethyl-formamide; at 100 ℃; for 12h;
DOI:10.1021/jo0626111

Reference yield: 82.0%

: 935680-00-5
(diethoxy-phosphoryl)-(2-[1,3]dioxolan-2-yl-phenyl)-acetic acid methyl ester

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 935680-01-6
2-(2-formylphenyl)acrylic acid methyl ester

Guidance literature:: (diethoxy-phosphoryl)-(2-[1,3]dioxolan-2-yl-phenyl)-acetic acid methyl ester; With sodium hydride; In various solvent(s); at 25 ℃; for 0.166667h;

formaldehyd; at 25 ℃; for 3h;
DOI:10.1021/jo0626111

Reference yield:

: 935680-00-5
(diethoxy-phosphoryl)-(2-[1,3]dioxolan-2-yl-phenyl)-acetic acid methyl ester

: 915358-69-9
2-[2-(tert-butoxycarbonyl(furan-2-yl)aminocarbonyl)phenyl]acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / various solvent(s) / 0.17 h / 25 °C

1.2: 82 percent / 3 h / 25 °C

2.1: 93 percent / H₂O₂; NaH₂PO₄*H₂O; NaClO₂ / acetone; H₂O / 1 h / 10 - 20 °C

3.1: oxalyl chloride; DMF / CH₂Cl₂ / 3 h / 20 °C

4.1: 64 percent / BuLi / tetrahydrofuran; hexane / 0.33 h / 0 °C

With sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; oxalyl dichloride; dihydrogen peroxide; sodium hydride; N,N-dimethyl-formamide; In tetrahydrofuran; hexane; dichloromethane; water; acetone;
DOI:10.1021/jo0626111