4-(6-(3-methoxy-4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

Base Information

Chemical Name:4-(6-(3-methoxy-4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile
CAS No.:1464154-94-6
Molecular Formula:C₂₅H₂₁N₅O₃
Molecular Weight:439.473
Hs Code.:

Synonyms:4-(6-(3-methoxy-4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

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Chemical Property of 4-(6-(3-methoxy-4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

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Technology Process of 4-(6-(3-methoxy-4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

There total 5 articles about 4-(6-(3-methoxy-4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.2%

: 1464154-89-9
(4-(3-iodoimidazo[1,2-b]pyridazin-6-yl)-2-methoxyphenyl)(morpholino)methanone

: 126747-14-6
4-cyanophenylboronic acid

: 1464154-94-6
4-(6-(3-methoxy-4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 90 ℃; for 16h; Inert atmosphere;

Reference yield:

: 72135-36-5
4-bromo-2-methoxybenzoic acid

: 1464154-94-6
4-(6-(3-methoxy-4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

2: potassium acetate; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / water; 1,4-dioxane / 16 h / 90 °C

4: N-iodo-succinimide / acetonitrile / 3 h / 70 °C

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / water; 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

With 4-methyl-morpholine; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; HATU; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1092564-35-6
(2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)(morpholino)methanone

: 1464154-94-6
4-(6-(3-methoxy-4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / water; 1,4-dioxane / 16 h / 90 °C

2: N-iodo-succinimide / acetonitrile / 3 h / 70 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / water; 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

With potassium phosphate; N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; acetonitrile;