(-)-(1S,3S,6R)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide

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Chemical Name:(-)-(1S,3S,6R)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide
CAS No.:1310359-17-1
Molecular Formula:C₁₃H₁₇FNO₃P
Molecular Weight:285.255
Hs Code.:

Synonyms:(-)-(1S,3S,6R)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide

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Chemical Property of (-)-(1S,3S,6R)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide

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Technology Process of (-)-(1S,3S,6R)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide

There total 4 articles about (-)-(1S,3S,6R)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1310359-08-0
(-)-(3S,4R)-3-hydroxy-1-(phenylmethyl)piperidine-4-methanol

: 1310359-16-0
(-)-(1S,3R,6R)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide

: 1310359-17-1
(-)-(1S,3S,6R)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide

Guidance literature:: With pyridine; phosphoryl dichloride fluoride; In diethyl ether; at 0 ℃; for 0.0333333h; optical yield given as %ee; Inert atmosphere;
DOI:10.1002/hlca.201000457

Reference yield:

: C₁₅H₁₆BrNO₄

: 1310359-16-0
(-)-(1S,3R,6R)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide

: 1310359-17-1
(-)-(1S,3S,6R)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: ((-)-(1S)-[1,1'-binaphthalene]-2,2'-diylbis[diphenylphosphine-κP])chloro[(1,2,3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene]ruthenium(1+) chloride; hydrogen

2: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / 0 °C / Reflux

3: pyridine; phosphoryl dichloride fluoride / diethyl ether / 0.03 h / 0 °C / Inert atmosphere

With pyridine; lithium aluminium tetrahydride; phosphoryl dichloride fluoride; ((-)-(1S)-[1,1'-binaphthalene]-2,2'-diylbis[diphenylphosphine-κP])chloro[(1,2,3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene]ruthenium(1+) chloride; hydrogen; In tetrahydrofuran; diethyl ether;
DOI:10.1002/hlca.201000457

Reference yield:

: 39514-19-7
ethyl 1-benzyl-3-oxo-4-piperidinecarboxylate

: 1310359-16-0
(-)-(1S,3R,6R)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide

: 1310359-17-1
(-)-(1S,3S,6R)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: baker's yeast / water / 30 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / 0 °C / Reflux

3: pyridine; phosphoryl dichloride fluoride / diethyl ether / 0.03 h / 0 °C / Inert atmosphere

With pyridine; lithium aluminium tetrahydride; phosphoryl dichloride fluoride; In tetrahydrofuran; diethyl ether; water;
DOI:10.1002/hlca.201000457