(2R)-2-amino-N-(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)butanamide

Base Information

Chemical Name:(2R)-2-amino-N-(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)butanamide
CAS No.:1311138-23-4
Molecular Formula:C₁₇H₂₁N₃O₃
Molecular Weight:315.372
Hs Code.:

Synonyms:(2R)-2-amino-N-(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)butanamide

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Chemical Property of (2R)-2-amino-N-(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)butanamide

Chemical Property:

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Technology Process of (2R)-2-amino-N-(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)butanamide

There total 5 articles about (2R)-2-amino-N-(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1311138-22-3
1,1-dimethylethyl ((1R)-1-{[(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)amino]carbonyl}propyl)carbamate

: 1311138-23-4
(2R)-2-amino-N-(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)butanamide

Guidance literature:: 1,1-dimethylethyl ((1R)-1-{[(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)amino]carbonyl}propyl)carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With ammonia; In methanol;

Reference yield:

: 19217-50-6
4-methyl-3-(methyloxy)phenol

: 1311138-23-4
(2R)-2-amino-N-(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)butanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 115 °C

2.1: water; ammonium chloride / iron / tetrahydrofuran / 8 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.25 h / 20 °C

3.2: 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With water; potassium carbonate; ammonium chloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; iron; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 16452-01-0
ortho-cresidine

: 1311138-23-4
(2R)-2-amino-N-(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)butanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; sodium nitrite; sulfuric acid / 1.5 h / 0 - 90 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 115 °C

3.1: water; ammonium chloride / iron / tetrahydrofuran / 8 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.25 h / 20 °C

4.2: 20 °C

5.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With sulfuric acid; water; potassium carbonate; ammonium chloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium nitrite; iron; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;