6-(cyclohexylamino)-4-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)picolinonitrile

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Chemical Name:6-(cyclohexylamino)-4-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)picolinonitrile
CAS No.:1262293-86-6
Molecular Formula:C₂₅H₂₃N₅O₂S
Molecular Weight:457.556
Hs Code.:

Synonyms:6-(cyclohexylamino)-4-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)picolinonitrile

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Chemical Property of 6-(cyclohexylamino)-4-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)picolinonitrile

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Technology Process of 6-(cyclohexylamino)-4-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)picolinonitrile

There total 4 articles about 6-(cyclohexylamino)-4-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)picolinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 557-21-1
zinc(II) cyanide

: 1262293-77-5
6-chloro-N-cyclohexyl-4-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine

: 1262293-86-6
6-(cyclohexylamino)-4-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)picolinonitrile

Guidance literature:: With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc; In N,N-dimethyl acetamide; at 170 ℃; for 0.5h; Microwave irradiation;
DOI:10.1021/ml300348c

Reference yield:

: 886547-94-0
1-(phenylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine

: 1262293-86-6
6-(cyclohexylamino)-4-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)picolinonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; N,N-dimethyl-formamide; ethanol / 80 °C

2: acetonitrile / 1 h / 170 °C / Microwave irradiation

3: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc / N,N-dimethyl acetamide / 0.5 h / 170 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate; zinc; In ethanol; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; acetonitrile; 1: |Suzuki Coupling;
DOI:10.1021/ml300348c

Reference yield:

: 98027-84-0
2,6-dichloro-4-iodopyridine

: 1262293-86-6
6-(cyclohexylamino)-4-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)picolinonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; N,N-dimethyl-formamide; ethanol / 80 °C

2: acetonitrile / 1 h / 170 °C / Microwave irradiation

3: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc / N,N-dimethyl acetamide / 0.5 h / 170 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate; zinc; In ethanol; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; acetonitrile; 1: |Suzuki Coupling;
DOI:10.1021/ml300348c