2-(1-chloro-3-phenyl-2-propyn-1-ylidene)-1,1,3,3-tetramethylindan

Base Information

• Chemical Name: 2-(1-chloro-3-phenyl-2-propyn-1-ylidene)-1,1,3,3-tetramethylindan
• CAS No.: 919301-29-4
• Molecular Formula: C₂₂H₂₁Cl
• Molecular Weight: 320.862
• Mol file: 919301-29-4.mol

Synonyms:2-(1-chloro-3-phenyl-2-propyn-1-ylidene)-1,1,3,3-tetramethylindan

Chemical Property of 2-(1-chloro-3-phenyl-2-propyn-1-ylidene)-1,1,3,3-tetramethylindan

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(1-chloro-3-phenyl-2-propyn-1-ylidene)-1,1,3,3-tetramethylindan

There total 3 articles about 2-(1-chloro-3-phenyl-2-propyn-1-ylidene)-1,1,3,3-tetramethylindan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(dichloromethyl)-1,1,3,3-tetramethyl-2-indanol (919301-25-0) → 2-(1-chloro-3-phenyl-2-propyn-1-ylidene)-1,1,3,3-tetramethylindan (919301-29-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / thionyl chloride; pyridine / 20 °C

2: 2,4,6-(t-Bu)3C₆H₂Li / diethyl ether; tetrahydrofuran / 72 h

With pyridine; thionyl chloride; In tetrahydrofuran; diethyl ether;

DOI:10.1021/ja0649116

Reference yield:

1,1,3,3-tetramethylindane-2-one (5689-12-3) → 2-(1-chloro-3-phenyl-2-propyn-1-ylidene)-1,1,3,3-tetramethylindan (919301-29-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 68 percent / lithium diisopropylamide / tetrahydrofuran / 2.25 h / -50 - -20 °C

2: 97 percent / thionyl chloride; pyridine / 20 °C

3: 2,4,6-(t-Bu)3C₆H₂Li / diethyl ether; tetrahydrofuran / 72 h

With pyridine; thionyl chloride; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether;

DOI:10.1021/ja0649116

Reference yield:

2-(dichloromethylidene)-1,1,3,3-tetramethylindane (242149-78-6) + lithium phenylacetylide (4440-01-1) → 2-(1-chloro-3-phenyl-2-propyn-1-ylidene)-1,1,3,3-tetramethylindan (919301-29-4)

Guidance literature:

With 2,4,6-(t-Bu)3C₆H₂Li; In tetrahydrofuran; diethyl ether; for 72h;

DOI:10.1021/ja0649116

upstream raw materials:

2-(dichloromethylidene)-1,1,3,3-tetramethylindane

lithium phenylacetylide

2-(dichloromethyl)-1,1,3,3-tetramethyl-2-indanol

1,1,3,3-tetramethylindane-2-one