indan-2-yl-[2-(1-methylpyrrolidin-2-yl)ethyl]phenylamine

Base Information

• Chemical Name: indan-2-yl-[2-(1-methylpyrrolidin-2-yl)ethyl]phenylamine
• CAS No.: 1393836-82-2
• Molecular Formula: C₂₂H₂₈N₂
• Molecular Weight: 320.478
• Mol file: 1393836-82-2.mol

Synonyms:indan-2-yl-[2-(1-methylpyrrolidin-2-yl)ethyl]phenylamine

Chemical Property of indan-2-yl-[2-(1-methylpyrrolidin-2-yl)ethyl]phenylamine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of indan-2-yl-[2-(1-methylpyrrolidin-2-yl)ethyl]phenylamine

There total 3 articles about indan-2-yl-[2-(1-methylpyrrolidin-2-yl)ethyl]phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.1%

indan-2-yl anilide (33237-72-8) + 2-(2-chloroethyl)-1-methylpyrrolidine hydrochloride (56824-22-7) → indan-2-yl-[2-(1-methylpyrrolidin-2-yl)ethyl]phenylamine (1393836-82-2)

Guidance literature:

indan-2-yl anilide; With sodium amide; In toluene; at 0 - 20 ℃; for 3h;

2-(2-chloroethyl)-1-methylpyrrolidine hydrochloride; In toluene; for 16h; Reflux;

Reference yield:

aniline (62-53-3) → indan-2-yl-[2-(1-methylpyrrolidin-2-yl)ethyl]phenylamine (1393836-82-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 20 °C / Cooling with ice

2.1: sodium amide / toluene / 3 h / 0 - 20 °C

2.2: 16 h / Reflux

With sodium tris(acetoxy)borohydride; sodium amide; acetic acid; In dichloromethane; toluene;

Reference yield:

2-indanone (615-13-4) → indan-2-yl-[2-(1-methylpyrrolidin-2-yl)ethyl]phenylamine (1393836-82-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 20 °C / Cooling with ice

2.1: sodium amide / toluene / 3 h / 0 - 20 °C

2.2: 16 h / Reflux

With sodium tris(acetoxy)borohydride; sodium amide; acetic acid; In dichloromethane; toluene;

upstream raw materials:

indan-2-yl anilide

2-(2-chloroethyl)-1-methylpyrrolidine hydrochloride

2-indanone

aniline

Downstream raw materials:

1,1-dimethyl-2-[2-((indan-2-yl)(phenyl)amino)ethyl]pyrrolidinium iodide

Refernces

• 1、 -. "Aminoindane Compounds and Use Thereof in Treating Pain". Page/Page column 64. . Retrieved 2012/09/05.