2-[2-(2-tert-butoxycarbonylamino-propionyloxy)-3-methyl-butyrylamino]-5-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-pentanoic acid tert-butyl ester

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Chemical Name:2-[2-(2-tert-butoxycarbonylamino-propionyloxy)-3-methyl-butyrylamino]-5-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-pentanoic acid tert-butyl ester
CAS No.:338735-88-9
Molecular Formula:C₃₀H₄₂F₃N₅O₉
Molecular Weight:673.687
Hs Code.:

2-[2-(2-<i>tert</i>-butoxycarbonylamino-propionyloxy)-3-methyl-butyrylamino]-5-[2-nitro-4-(3-trifluoromethyl-3<i>H</i>-diazirin-3-yl)-phenyl]-pentanoic acid <i>tert</i>-butyl ester

Synonyms:2-[2-(2-tert-butoxycarbonylamino-propionyloxy)-3-methyl-butyrylamino]-5-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-pentanoic acid tert-butyl ester

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Chemical Property of 2-[2-(2-tert-butoxycarbonylamino-propionyloxy)-3-methyl-butyrylamino]-5-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-pentanoic acid tert-butyl ester

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Technology Process of 2-[2-(2-tert-butoxycarbonylamino-propionyloxy)-3-methyl-butyrylamino]-5-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-pentanoic acid tert-butyl ester

There total 9 articles about 2-[2-(2-tert-butoxycarbonylamino-propionyloxy)-3-methyl-butyrylamino]-5-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-pentanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 60008-24-4
Boc-L-Ala-L-Hmb-OH

: 2-amino-5-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-pentanoic acid tert-butyl ester; hydrochloride

: 338735-88-9
2-[2-(2-tert-butoxycarbonylamino-propionyloxy)-3-methyl-butyrylamino]-5-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-pentanoic acid tert-butyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.3987/com-00-s(i)90

Reference yield:

: 60008-23-3
Boc-L-Ala-L-Hmb-OBzl

: 338735-88-9
2-[2-(2-tert-butoxycarbonylamino-propionyloxy)-3-methyl-butyrylamino]-5-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / H₂ / Pd-C / methanol; H₂O / 12 h / 20 °C

2: 89 percent / HOBt; NMM; DCC / tetrahydrofuran / 12 h / 20 °C

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; water;
DOI:10.3987/com-00-s(i)90

Reference yield:

: 271252-22-3
3-(azi-2,2,2-trifluoroethyl)-6-(3-bromopropyl)-1-nitrobenzene

: 338735-88-9
2-[2-(2-tert-butoxycarbonylamino-propionyloxy)-3-methyl-butyrylamino]-5-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 53 percent / NaH / dimethylformamide / 24 h / 20 °C

2: 100 percent / aq. NaOH / ethanol; H₂O / 20 °C

3: dioxane / 1 h / 80 °C

4: 29 percent / aq. NaOH; CoCl₂; Aspergillus genus enzyme / aq. phosphate buffer / 48 h / 35 - 38 °C / pH 6.7

5: 97 percent / Et₃N / dioxane; H₂O / 12 h / 20 °C

6: 93 percent / CH₂Cl₂ / 12 h / Heating

7: 81 percent / HCl / ethyl acetate / 1 h / 20 °C

8: 89 percent / HOBt; NMM; DCC / tetrahydrofuran / 12 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; Aspergillus genus enzyme; sodium hydride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; phosphate buffer; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.3987/com-00-s(i)90