acetic acid (S)-4-[2,3-dioxo-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-2,3-dihydroindol-1-yl-methyl]phenyl ester

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Chemical Name:acetic acid (S)-4-[2,3-dioxo-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-2,3-dihydroindol-1-yl-methyl]phenyl ester
CAS No.:872254-18-7
Molecular Formula:C₂₈H₂₆N₂O₇S
Molecular Weight:534.59
Hs Code.:

Synonyms:acetic acid (S)-4-[2,3-dioxo-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-2,3-dihydroindol-1-yl-methyl]phenyl ester

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Chemical Property of acetic acid (S)-4-[2,3-dioxo-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-2,3-dihydroindol-1-yl-methyl]phenyl ester

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Technology Process of acetic acid (S)-4-[2,3-dioxo-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-2,3-dihydroindol-1-yl-methyl]phenyl ester

There total 7 articles about acetic acid (S)-4-[2,3-dioxo-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-2,3-dihydroindol-1-yl-methyl]phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 39720-27-9
4-acetoxybenzyl chloride

: 220509-98-8
5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione

: 872254-18-7
acetic acid (S)-4-[2,3-dioxo-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-2,3-dihydroindol-1-yl-methyl]phenyl ester

Guidance literature:: 5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.25h; Inert atmosphere;

4-acetoxybenzyl chloride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1039/b819024k

Reference yield:

: 69610-40-8
N-(tert-butoxycarbonyl)-L-prolinol

: 872254-18-7
acetic acid (S)-4-[2,3-dioxo-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-2,3-dihydroindol-1-yl-methyl]phenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 100 percent / pyridine / CH₂Cl₂ / 20 °C

2.1: NaH / tetrahydrofuran / 0.67 h / 0 - 20 °C

2.2: 54 percent / tetrahydrofuran / 24 h / Heating

3.1: CF₃CO₂H / CH₂Cl₂ / 0.25 h / 0 °C

4.1: 1.7 g / Et₃N / CH₂Cl₂; tetrahydrofuran / 20 °C

5.1: NaH / dimethylformamide / 0.25 h / 20 °C

5.2: 42 percent / dimethylformamide / 20 °C

With pyridine; sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0506625

Reference yield:

: 132898-96-5
5-chlorosulfonylisatin

: 872254-18-7
acetic acid (S)-4-[2,3-dioxo-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-2,3-dihydroindol-1-yl-methyl]phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1.7 g / Et₃N / CH₂Cl₂; tetrahydrofuran / 20 °C

2.1: NaH / dimethylformamide / 0.25 h / 20 °C

2.2: 42 percent / dimethylformamide / 20 °C

With sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0506625