N-(4-(4-(6-fluoropyridin-2-yl)piperazin-1-yl)butyl)cyclohexanecarboxamide

Base Information

Chemical Name:N-(4-(4-(6-fluoropyridin-2-yl)piperazin-1-yl)butyl)cyclohexanecarboxamide
CAS No.:1351410-60-0
Molecular Formula:C₂₀H₃₁FN₄O
Molecular Weight:362.491
Hs Code.:

Synonyms:N-(4-(4-(6-fluoropyridin-2-yl)piperazin-1-yl)butyl)cyclohexanecarboxamide

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Chemical Property of N-(4-(4-(6-fluoropyridin-2-yl)piperazin-1-yl)butyl)cyclohexanecarboxamide

Chemical Property:

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Technology Process of N-(4-(4-(6-fluoropyridin-2-yl)piperazin-1-yl)butyl)cyclohexanecarboxamide

There total 3 articles about N-(4-(4-(6-fluoropyridin-2-yl)piperazin-1-yl)butyl)cyclohexanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1351411-81-8
4-(4-(6-fluoropyridin-2-yl)piperazin-1-yl)butan-1-amine

: 2719-27-9
cyclohexanylcarbonyl chloride

: 1351410-60-0
N-(4-(4-(6-fluoropyridin-2-yl)piperazin-1-yl)butyl)cyclohexanecarboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 223514-16-7
1-(6-fluoropyridin-2-yl)piperazine

: 1351410-60-0
N-(4-(4-(6-fluoropyridin-2-yl)piperazin-1-yl)butyl)cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 17 h / 80 °C / Inert atmosphere

2: hydrazine hydrate / ethanol / 6 h / 20 - 80 °C / Inert atmosphere

3: triethylamine / dichloromethane / 1 h / 20 °C

With potassium carbonate; hydrazine hydrate; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1351410-62-2
2-(4-(4-(6-fluoropyridin-2-yl)piperazin-1-yl)butyl)isoindoline-1,3-dione

: 1351410-60-0
N-(4-(4-(6-fluoropyridin-2-yl)piperazin-1-yl)butyl)cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 6 h / 20 - 80 °C / Inert atmosphere

2: triethylamine / dichloromethane / 1 h / 20 °C

With hydrazine hydrate; triethylamine; In ethanol; dichloromethane;