3-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-pent-4-enoic acid

Base Information

Chemical Name:3-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-pent-4-enoic acid
CAS No.:910789-87-6
Molecular Formula:C₂₄H₃₂O₃Si
Molecular Weight:396.602
Hs Code.:

Synonyms:3-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-pent-4-enoic acid

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Chemical Property of 3-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-pent-4-enoic acid

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Technology Process of 3-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-pent-4-enoic acid

There total 5 articles about 3-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-pent-4-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 952574-31-1
isobutyric acid 4-(tert-butyl-diphenyl-silanyloxy)-but-2-enyl ester

: 910789-87-6
3-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-pent-4-enoic acid

Guidance literature:: isobutyric acid 4-(tert-butyl-diphenyl-silanyloxy)-but-2-enyl ester; With potassium hexamethylsilazane; In toluene; at -78 ℃; for 1h;

With chloro-trimethyl-silane; In toluene; at -78 - 80 ℃; for 3.16h;

Reference yield: 90.0%

: 910789-86-5
isobutyric acid 4-(tert-butyl-diphenyl-silanyloxy)-but-2-enyl ester

: 910789-87-6
3-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-pent-4-enoic acid

Guidance literature:: isobutyric acid 4-(tert-butyl-diphenyl-silanyloxy)-but-2-enyl ester; With potassium hexamethylsilazane; In toluene; at -78 ℃; for 1h;

With chloro-trimethyl-silane; In toluene; at -78 - 20 ℃; for 1h;

In toluene; at 80 ℃; for 5h;
DOI:10.1016/j.bmcl.2006.08.034

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 910789-87-6
3-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-pent-4-enoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / CH₂Cl₂ / 0 - 20 °C

2.1: 74.2 g / iPr₂NEt; DMAP / CH₂Cl₂ / 17 h / 0 - 8 °C

3.1: KHMDS / toluene / 2 h / -71 °C

3.2: 88 percent / TMSCl / toluene / -71 - 80 °C

With dmap; potassium hexamethylsilazane; sodium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene; 3.1: Ireland-Claisen rearrangement;
DOI:10.1021/ol061429j