bromo{6-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]pyridin-2-yl}(6-phenylpyridin-2-yl)pyridin-2-ylmethane

Base Information

• Chemical Name: bromo{6-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]pyridin-2-yl}(6-phenylpyridin-2-yl)pyridin-2-ylmethane
• CAS No.: 415679-69-5
• Molecular Formula: C₃₂H₃₄BrN₃O
• Molecular Weight: 556.545

Synonyms:bromo{6-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]pyridin-2-yl}(6-phenylpyridin-2-yl)pyridin-2-ylmethane

Chemical Property of bromo{6-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]pyridin-2-yl}(6-phenylpyridin-2-yl)pyridin-2-ylmethane

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Technology Process of bromo{6-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]pyridin-2-yl}(6-phenylpyridin-2-yl)pyridin-2-ylmethane

There total 1 articles about bromo{6-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]pyridin-2-yl}(6-phenylpyridin-2-yl)pyridin-2-ylmethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

{6-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]pyridin-2-yl}(6-phenylpyridin-2-yl)pyridin-2-ylmethanol → bromo{6-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]pyridin-2-yl}(6-phenylpyridin-2-yl)pyridin-2-ylmethane (415679-69-5)

Guidance literature:

{6-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]pyridin-2-yl}(6-phenylpyridin-2-yl)pyridin-2-ylmethanol; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.25h;

With dibromo sulfoxide; In diethyl ether; hexane; at -78 - 20 ℃; for 16h;

DOI:10.1055/s-2001-18716

Reference yield: 73.0%

bromo{6-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]pyridin-2-yl}(6-phenylpyridin-2-yl)pyridin-2-ylmethane (415679-69-5) → {6-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]pyridin-2-yl}(6-phenylpyridin-2-yl)pyridin-2-ylmethane

Guidance literature:

bromo{6-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]pyridin-2-yl}(6-phenylpyridin-2-yl)pyridin-2-ylmethane; With n-butyllithium; In diethyl ether; hexane; at -90 - 20 ℃;

With water; In diethyl ether; hexane;

DOI:10.1055/s-2001-18716

Reference yield:

trimethylene oxide (503-30-0) + bromo{6-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]pyridin-2-yl}(6-phenylpyridin-2-yl)pyridin-2-ylmethane (415679-69-5) → (S)-4-{6-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]pyridin-2-yl}-4-(6-phenylpyridin-2-yl)-4-pyridin-2-ylbutan-1-ol + (R)-4-{6-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]pyridin-2-yl}-4-(6-phenylpyridin-2-yl)-4-pyridin-2-ylbutan-1-ol

Guidance literature:

bromo{6-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]pyridin-2-yl}(6-phenylpyridin-2-yl)pyridin-2-ylmethane; With n-butyllithium; In diethyl ether; hexane; at -90 ℃; for 0.5h;

trimethylene oxide; With boron trifluoride diethyl etherate; In diethyl ether; hexane; at -90 - 20 ℃; for 5h; Title compound not separated from byproducts;

DOI:10.1055/s-2001-18716

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