Chemical Property of Scriptaid
Chemical Property:
- Melting Point:160-161℃
- Refractive Index:1.646
- PSA：88.40000
- Density:1.338 g/cm3
- LogP:2.40940
- Storage Temp.:−20°C
- Sensitive.:Light Sensitive
- Solubility.:Soluble in DMSO (up to 4 mg/ml).
- XLogP3:2
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:6
- Exact Mass:326.12665706
- Heavy Atom Count:24
- Complexity:477
- Purity/Quality:
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99%, *data from raw suppliers
Scriptide *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1=CC2=C3C(=C1)C(=O)N(C(=O)C3=CC=C2)CCCCCC(=O)NO
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Description
Scriptaid is a histone deacetylase inhibitor that has an optimal concentration of 6-8 μM in a cell-based assay, is less toxic than trichostatin A, and works in a wide variety of biological systems. It induces cell cycle arrest in colon cancer cells in culture and inhibits tumor growth in vitro and in vivo. Scriptaid also facilitates the cloning of inbred mouse strains produced by somatic cell nuclear transfer.
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Uses
Scriptaid has been used in post activation of oocytes and embryo culture. Histone deacetylase inhibitor. A cell-permeable, relatively non-toxic HDAC inhibitor that facilitates transcriptional activation (TGFβ/Smad4) in both stable and transient receptor assays in a concentration-dependent manner.
