3-[11-(tosyloxy)undecyl]-8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one

Base Information

• Chemical Name: 3-[11-(tosyloxy)undecyl]-8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one
• CAS No.: 1446684-98-5
• Molecular Formula: C₄₁H₅₄FN₃O₅S
• Molecular Weight: 719.961
• Mol file: 1446684-98-5.mol

Synonyms:3-[11-(tosyloxy)undecyl]-8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one

Chemical Property of 3-[11-(tosyloxy)undecyl]-8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[11-(tosyloxy)undecyl]-8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one

There total 4 articles about 3-[11-(tosyloxy)undecyl]-8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-[11-hydroxyundecyl]-8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one (1446684-96-3) + p-toluenesulfonyl chloride (98-59-9) → 3-[11-(tosyloxy)undecyl]-8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one (1446684-98-5)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 ℃; for 3h;

DOI:10.1021/jo400646k

Reference yield:

spiperone (749-02-0) → 3-[11-(tosyloxy)undecyl]-8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one (1446684-98-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / N,N-dimethyl-formamide / 120 °C / Inert atmosphere

2: triethylamine; dmap / dichloromethane / 3 h / 0 °C

With dmap; triethylamine; potassium hydroxide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo400646k

Reference yield:

4-(4-fluorophenyl)-4-oxo-n-butyl chloride (3874-54-2,41167-07-1) → 3-[11-(tosyloxy)undecyl]-8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one (1446684-98-5)

Guidance literature:

Multi-step reaction with 3 steps

1: diisopropylamine / N,N-dimethyl-formamide / 17 h / 80 °C / Inert atmosphere

2: potassium hydroxide / N,N-dimethyl-formamide / 120 °C / Inert atmosphere

3: triethylamine; dmap / dichloromethane / 3 h / 0 °C

With dmap; triethylamine; diisopropylamine; potassium hydroxide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo400646k

upstream raw materials:

spiperone

1-Phenyl-1,3,8-triaza-spiro[4.5]decan-4-one

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

3-[11-hydroxyundecyl]-8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one