rac-2-methoxy-N-[3-(4-methoxy-phenyl)-1-methyl-piperidin-3-yl]-6-methylsulfanyl-4-trifluoromethyl-benzamide

Base Information

Chemical Name:rac-2-methoxy-N-[3-(4-methoxy-phenyl)-1-methyl-piperidin-3-yl]-6-methylsulfanyl-4-trifluoromethyl-benzamide
CAS No.:1236301-74-8
Molecular Formula:C₂₃H₂₇F₃N₂O₃S
Molecular Weight:468.54
Hs Code.:

Synonyms:rac-2-methoxy-N-[3-(4-methoxy-phenyl)-1-methyl-piperidin-3-yl]-6-methylsulfanyl-4-trifluoromethyl-benzamide

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Chemical Property of rac-2-methoxy-N-[3-(4-methoxy-phenyl)-1-methyl-piperidin-3-yl]-6-methylsulfanyl-4-trifluoromethyl-benzamide

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Technology Process of rac-2-methoxy-N-[3-(4-methoxy-phenyl)-1-methyl-piperidin-3-yl]-6-methylsulfanyl-4-trifluoromethyl-benzamide

There total 6 articles about rac-2-methoxy-N-[3-(4-methoxy-phenyl)-1-methyl-piperidin-3-yl]-6-methylsulfanyl-4-trifluoromethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1236302-44-5
rac-3-(4-methoxy-phenyl)-1-methyl-piperidin-3-ylamine

: 1236303-05-1
2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzoyl chloride

: 1236301-74-8
rac-2-methoxy-N-[3-(4-methoxy-phenyl)-1-methyl-piperidin-3-yl]-6-methylsulfanyl-4-trifluoromethyl-benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/ml500005m

Reference yield:

: 104-92-7
1-bromo-4-methoxy-benzene

: 1236301-74-8
rac-2-methoxy-N-[3-(4-methoxy-phenyl)-1-methyl-piperidin-3-yl]-6-methylsulfanyl-4-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; di-tert-butyl (2'-methyl-[1,1'-biphenyl]-2-yl)phosphine; caesium carbonate / 1,2-dimethoxyethane / 50 °C / Inert atmosphere

2.1: water; 1,4-dioxane / 0.08 h / 20 °C

2.2: 6 h / 65 °C

3.1: hydrogenchloride; zinc / water; 1,4-dioxane / 0.5 h / 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / Reflux

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium aluminium tetrahydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; di-tert-butyl (2'-methyl-[1,1'-biphenyl]-2-yl)phosphine; zinc; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; 2.1: |Mannich Aminomethylation / 2.2: |Mannich Aminomethylation;
DOI:10.1021/ml500005m

Reference yield:

: rac-4-(4-methoxy-phenyl)-4-nitro-butyric acid methyl ester

: 1236301-74-8
rac-2-methoxy-N-[3-(4-methoxy-phenyl)-1-methyl-piperidin-3-yl]-6-methylsulfanyl-4-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; 1,4-dioxane / 0.08 h / 20 °C

1.2: 6 h / 65 °C

2.1: hydrogenchloride; zinc / water; 1,4-dioxane / 0.5 h / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / Reflux

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 1.1: |Mannich Aminomethylation / 1.2: |Mannich Aminomethylation;
DOI:10.1021/ml500005m