O-{pyridin-3-yl-[4-(quinolin-2-ylmethoxy)-phenyl]-methyl}-hydroxylamine

Base Information

• Chemical Name: O-{pyridin-3-yl-[4-(quinolin-2-ylmethoxy)-phenyl]-methyl}-hydroxylamine
• CAS No.: 1026459-46-0
• Molecular Formula: C₂₂H₁₉N₃O₂
• Molecular Weight: 357.412

Synonyms:O-{pyridin-3-yl-[4-(quinolin-2-ylmethoxy)-phenyl]-methyl}-hydroxylamine

Chemical Property of O-{pyridin-3-yl-[4-(quinolin-2-ylmethoxy)-phenyl]-methyl}-hydroxylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O-{pyridin-3-yl-[4-(quinolin-2-ylmethoxy)-phenyl]-methyl}-hydroxylamine

There total 5 articles about O-{pyridin-3-yl-[4-(quinolin-2-ylmethoxy)-phenyl]-methyl}-hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-{pyridin-3-yl-[4-(quinolin-2-ylmethoxy)-phenyl]-methoxy}-isoindole-1,3-dione → O-{pyridin-3-yl-[4-(quinolin-2-ylmethoxy)-phenyl]-methyl}-hydroxylamine (1026459-46-0)

Guidance literature:

With hydrazine hydrate; In ethanol; dichloromethane; for 0.5h; Heating;

DOI:10.1021/jm9904102

Reference yield:

2-(chloromethyl)quinoline monohydrochloride (3747-74-8) → O-{pyridin-3-yl-[4-(quinolin-2-ylmethoxy)-phenyl]-methyl}-hydroxylamine (1026459-46-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 74 percent / K₂CO₃ / dimethylformamide / 16 h / 20 °C

2.1: AlCl₃ / CH₂Cl₂ / 4 h / 20 °C

2.2: NaBH₄ / ethanol / Heating

3.1: Ph₃P; diethyl azodicarboxylate / tetrahydrofuran / 14 h / 20 °C

4.1: hydrazine hydrate / ethanol; CH₂Cl₂ / 0.5 h / Heating

With aluminium trichloride; potassium carbonate; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; 1.1: Alkylation / 2.1: Addition / 2.2: Reduction / 3.1: Mitsunobu reaction / 4.1: Substitution;

DOI:10.1021/jm9904102

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → O-{pyridin-3-yl-[4-(quinolin-2-ylmethoxy)-phenyl]-methyl}-hydroxylamine (1026459-46-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 74 percent / K₂CO₃ / dimethylformamide / 16 h / 20 °C

2.1: AlCl₃ / CH₂Cl₂ / 4 h / 20 °C

2.2: NaBH₄ / ethanol / Heating

3.1: Ph₃P; diethyl azodicarboxylate / tetrahydrofuran / 14 h / 20 °C

4.1: hydrazine hydrate / ethanol; CH₂Cl₂ / 0.5 h / Heating

With aluminium trichloride; potassium carbonate; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; 1.1: Alkylation / 2.1: Addition / 2.2: Reduction / 3.1: Mitsunobu reaction / 4.1: Substitution;

DOI:10.1021/jm9904102

upstream raw materials:

2-(chloromethyl)quinoline monohydrochloride

4-hydroxy-benzaldehyde

4-[(2-quinolinyl)-methoxy]-benzaldehyde

pyridin-3-yl-[4-(quinolin-2-ylmethoxy)-phenyl]-methanol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1026459-46-0 O-{pyridin-3-yl-[4-(quinolin-2-ylmethoxy)-phenyl]-methyl}-hydroxylamine

Send

Send

Metric Ton KG G Pound L ML

Send

Send