4-Chloro-3(2H)-benzofuranone

Base Information

• Chemical Name: 4-Chloro-3(2H)-benzofuranone
• CAS No.: 3260-90-0
• Molecular Formula: C8H5 Cl O2
• Molecular Weight: 168.579
• Hs Code.: 2932999099
• Mol file: 3260-90-0.mol

Synonyms:4-Chloro-3(2H)-benzofuranone;4-Bromo-3-Benzofuranone

Chemical Property of 4-Chloro-3(2H)-benzofuranone

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 322.581°C at 760 mmHg
• Flash Point: 148.892°C
• PSA: 26.30000
• Density: 1.743g/cm³
• LogP: 1.91510
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4-chloro-2,3-dihydro-1-benzofuran-3-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Chloro-3(2H)-benzofuranone

There total 3 articles about 4-Chloro-3(2H)-benzofuranone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-chloro-2-ethynylphenol → 4-chloro-3-benzofuranone (3260-90-0)

Guidance literature:

With pyridine N-oxide; mercuric triflate; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

2-chloro-6-hydroxybenzaldehyde (18362-30-6) → 4-chloro-3-benzofuranone (3260-90-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triphenylphosphine / dichloromethane / 2.33 h / 0 °C

1.2: 1 h / -78 °C

2.1: 2-chloropyridine-N-oxide; mercuric triflate / dichloromethane / 1 h / 23 °C

With 2-chloropyridine-N-oxide; mercuric triflate; triphenylphosphine; In dichloromethane;

DOI:10.1021/acs.orglett.0c01096

Reference yield:

→ 4-chloro-3-benzofuranone (3260-90-0)

Guidance literature:

2-Chlor-6-methoxy-benzoesaeure, 1.) Thionylchlorid, 2.) Diazo?, 3.) Essigsaeure;

DOI:10.1039/JR9650004939

upstream raw materials:

2-chloro-6-hydroxybenzaldehyde

Refernces

• 1、 Dai, Ning,Hu, Weican,Qian, Guoying,Rong, Zhouting. "A Hg(OTf)2-Catalyzed Enolate Umpolung Reaction Enables the Synthesis of Coumaran-3-ones and Indolin-3-ones". supporting information. p. 3286 - 3290. Retrieved 2020/04/21.