Technology Process of 5-(4-([1,1'-biphenyl]-3-ylmethoxy)benzyl)thiazolidine-2,4-dione
There total 6 articles about 5-(4-([1,1'-biphenyl]-3-ylmethoxy)benzyl)thiazolidine-2,4-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydride;
In
dimethyl sulfoxide;
at 20 - 50 ℃;
for 2h;
- Guidance literature:
-
C23H17NO3S;
With
cobalt(II) chloride hexahydrate; butane-2,3-dione dioxime; sodium hydroxide;
In
tetrahydrofuran; N,N-dimethyl-formamide;
for 0.5h;
With
sodium tetrahydroborate;
In
tetrahydrofuran; water; N,N-dimethyl-formamide;
at 35 - 40 ℃;
for 16h;
DOI:10.1016/j.ejmech.2015.12.049
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene; tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere
2.1: tetrakis(triphenylphosphine) palladium(0) / water; toluene; methanol / 16 h / Inert atmosphere; Reflux
3.1: benzoic acid; piperidine / toluene / 16 h / Reflux; Dean-Stark
4.1: sodium hydroxide; cobalt(II) chloride hexahydrate; butane-2,3-dione dioxime / N,N-dimethyl-formamide; tetrahydrofuran / 0.5 h
4.2: 16 h / 35 - 40 °C
With
piperidine; tetrakis(triphenylphosphine) palladium(0); cobalt(II) chloride hexahydrate; di-isopropyl azodicarboxylate; butane-2,3-dione dioxime; triphenylphosphine; benzoic acid; sodium hydroxide;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;
1.1: |Mitsunobu Displacement / 2.1: |Suzuki-Miyaura Coupling / 3.1: |Knoevenagel Condensation;
DOI:10.1016/j.ejmech.2015.12.049
