trans-N-benzyl-5-<(trifluoroacetoxy)methyl>-3-<(benzyloxycarbonyl)amino>pyrrolidin-2-one

Base Information

Chemical Name:trans-N-benzyl-5-<(trifluoroacetoxy)methyl>-3-<(benzyloxycarbonyl)amino>pyrrolidin-2-one
CAS No.:127133-50-0
Molecular Formula:C₂₂H₂₁F₃N₂O₅
Molecular Weight:450.414
Hs Code.:

Synonyms:trans-N-benzyl-5-<(trifluoroacetoxy)methyl>-3-<(benzyloxycarbonyl)amino>pyrrolidin-2-one

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Chemical Property of trans-N-benzyl-5-<(trifluoroacetoxy)methyl>-3-<(benzyloxycarbonyl)amino>pyrrolidin-2-one

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Technology Process of trans-N-benzyl-5-<(trifluoroacetoxy)methyl>-3-<(benzyloxycarbonyl)amino>pyrrolidin-2-one

There total 4 articles about trans-N-benzyl-5-<(trifluoroacetoxy)methyl>-3-<(benzyloxycarbonyl)amino>pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 127133-31-7
N-Benzyl-2-benzyloxycarbonylamino-thioacetimidic acid allyl ester

: 127133-50-0
trans-N-benzyl-5-<(trifluoroacetoxy)methyl>-3-<(benzyloxycarbonyl)amino>pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 90 °C

2: K₂CO₃ / 15 h / Ambient temperature

3: iodine / tetrahydrofuran / 48 h / 5 °C

4: 61 percent / dimethylformamide / 20 h / Ambient temperature

With iodine; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo00299a019

Reference yield:

: 127133-25-9
N-benzyl-thioacetamide

: 127133-50-0
trans-N-benzyl-5-<(trifluoroacetoxy)methyl>-3-<(benzyloxycarbonyl)amino>pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: K₂CO₃ / acetone / Ambient temperature

2: 90 °C

3: K₂CO₃ / 15 h / Ambient temperature

4: iodine / tetrahydrofuran / 48 h / 5 °C

5: 61 percent / dimethylformamide / 20 h / Ambient temperature

With iodine; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00299a019

Reference yield:

: 127133-37-3
N-benzyl-2-<(benzyloxycarbonyl)amino>pent-4-enethioamide

: 127133-50-0
trans-N-benzyl-5-<(trifluoroacetoxy)methyl>-3-<(benzyloxycarbonyl)amino>pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / 15 h / Ambient temperature

2: iodine / tetrahydrofuran / 48 h / 5 °C

3: 61 percent / dimethylformamide / 20 h / Ambient temperature

With iodine; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo00299a019