2-Methylpyrimidine-4-carboxaldehyde

Base Information

• Chemical Name: 2-Methylpyrimidine-4-carboxaldehyde
• CAS No.: 1004-17-7
• Molecular Formula: C6H6N2O
• Molecular Weight: 122.12
• Hs Code.: 2933599090
• Mol file: 1004-17-7.mol

Synonyms:4-Formyl-2-methylpyrimidine;2-methyl-pyrimidine-4-carbaldehyde;

Chemical Property of 2-Methylpyrimidine-4-carboxaldehyde

Chemical Property:

• Vapor Pressure: 0.162mmHg at 25°C
• Refractive Index: 1.569
• Boiling Point: 213.728 °C at 760 mmHg
• PKA: 0.16±0.23(Predicted)
• Flash Point: 84.976 °C
• PSA: 42.85000
• Density: 1.176 g/cm³
• LogP: 0.59750
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Methylpyrimidine-4-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methylpyrimidine-4-carboxaldehyde

There total 2 articles about 2-Methylpyrimidine-4-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(dimethoxymethyl)-2-methylpyrimidine (175277-33-5) → 2-methyl-4-pyrimidinecarboxaldehyde (1004-17-7)

Guidance literature:

With hydrogenchloride; at 45 - 50 ℃;

DOI:10.1016/S0960-894X(98)00549-6

Reference yield:

→ 2-methyl-4-pyrimidinecarboxaldehyde (1004-17-7)

Guidance literature:

Reference yield:

2-methyl-4-pyrimidinecarboxaldehyde (1004-17-7) + benzylamine (100-46-9) → C13H13N3

Guidance literature:

With acetic acid; In 1,2-dichloro-ethane; at 25 ℃; for 1h;

DOI:10.1016/j.tet.2011.05.074

upstream raw materials:

4-(dimethoxymethyl)-2-methylpyrimidine

Downstream raw materials:

(phenylamino-(2-methyl-pyrimidin-4-yl)-methyl)-phosphonic acid diphenyl ester

3-(2-Methyl-pyrimidin-5-yl)-propenal

N-benzyl-1-(2-methyl-4-pyrimidinyl)methanamine

(R)-N-((1R,2R)-3-((S)-4-benzyl-5,5-dimethyl-2-oxooxazolidin-3-yl)-2-methyl-1-(2-methylpyrimidin-4-yl)-3-oxopropyl)-2-methylpropane-2-sulfinamide

Refernces

• 1、 -. "PYRIMIDINYLPYRAZOLES AS TGF-BETA INHIBITORS". Page/Page column 29-30. . Retrieved 2010/10/20.