3-(5-amino-2-fluorophenyl)-5-tert-butoxycarbonylamino-3-difluoromethyl-3,6-dihydro-2H-pyrazine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:3-(5-amino-2-fluorophenyl)-5-tert-butoxycarbonylamino-3-difluoromethyl-3,6-dihydro-2H-pyrazine-1-carboxylic acid tert-butyl ester
CAS No.:1313526-09-8
Molecular Formula:C₂₁H₂₉F₃N₄O₄
Molecular Weight:458.481
Hs Code.:

Synonyms:3-(5-amino-2-fluorophenyl)-5-tert-butoxycarbonylamino-3-difluoromethyl-3,6-dihydro-2H-pyrazine-1-carboxylic acid tert-butyl ester

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Chemical Property of 3-(5-amino-2-fluorophenyl)-5-tert-butoxycarbonylamino-3-difluoromethyl-3,6-dihydro-2H-pyrazine-1-carboxylic acid tert-butyl ester

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Technology Process of 3-(5-amino-2-fluorophenyl)-5-tert-butoxycarbonylamino-3-difluoromethyl-3,6-dihydro-2H-pyrazine-1-carboxylic acid tert-butyl ester

There total 12 articles about 3-(5-amino-2-fluorophenyl)-5-tert-butoxycarbonylamino-3-difluoromethyl-3,6-dihydro-2H-pyrazine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₂₇F₃N₆O₄

: 1313526-09-8
3-(5-amino-2-fluorophenyl)-5-tert-butoxycarbonylamino-3-difluoromethyl-3,6-dihydro-2H-pyrazine-1-carboxylic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol;

Reference yield:

: 460-00-4
1-Bromo-4-fluorobenzene

: 1313526-09-8
3-(5-amino-2-fluorophenyl)-5-tert-butoxycarbonylamino-3-difluoromethyl-3,6-dihydro-2H-pyrazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 12 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 2.5 h / -65 °C

1.2: -80 - -40 °C

2.1: toluene / 4 h / 105 °C / Industry scale

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 2 h / 25 °C

4.1: zinc; acetic acid / 2 h / 20 - 40 °C

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1.5 h / 80 °C

6.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h

7.1: N-ethyl-N,N-diisopropylamine / acetonitrile

8.1: Lawessons reagent / tetrahydrofuran

9.1: ammonia / methanol / 15 h / 20 °C

10.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 4 h / 20 °C / Cooling with ice

11.1: sodium azide / copper(l) iodide; sodium L-ascorbate; (±)-N,N-dimethyl-trans-1,2-diaminocyclohexane / ethanol; water / 0.5 h / 70 °C / Inert atmosphere

12.1: hydrogen / palladium 10% on activated carbon / ethanol

With Lawessons reagent; hydrogenchloride; n-butyllithium; sodium azide; ammonia; hydrogen; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; diisopropylamine; N-ethyl-N,N-diisopropylamine; zinc; copper(l) iodide; palladium 10% on activated carbon; (±)-N,N-dimethyl-trans-1,2-diaminocyclohexane; sodium L-ascorbate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 1262858-97-8
1-(5-bromo-2-fluorophenyl)-2,2-difluoroethanone

: 1313526-09-8
3-(5-amino-2-fluorophenyl)-5-tert-butoxycarbonylamino-3-difluoromethyl-3,6-dihydro-2H-pyrazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: toluene / 4 h / 105 °C / Industry scale

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / 2 h / 25 °C

3: zinc; acetic acid / 2 h / 20 - 40 °C

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 1.5 h / 80 °C

5: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h

6: N-ethyl-N,N-diisopropylamine / acetonitrile

7: Lawessons reagent / tetrahydrofuran

8: ammonia / methanol / 15 h / 20 °C

9: N-ethyl-N,N-diisopropylamine / acetonitrile / 4 h / 20 °C / Cooling with ice

10: sodium azide / copper(l) iodide; sodium L-ascorbate; (±)-N,N-dimethyl-trans-1,2-diaminocyclohexane / ethanol; water / 0.5 h / 70 °C / Inert atmosphere

11: hydrogen / palladium 10% on activated carbon / ethanol

With Lawessons reagent; hydrogenchloride; sodium azide; ammonia; hydrogen; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; zinc; copper(l) iodide; palladium 10% on activated carbon; (±)-N,N-dimethyl-trans-1,2-diaminocyclohexane; sodium L-ascorbate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; toluene; acetonitrile;