2,4-diamino-1,6-dihydro-5-(2-hydroxy-1-phenylethyl)-6-oxo-3-pyridinecarbonitrile

Base Information

• Chemical Name: 2,4-diamino-1,6-dihydro-5-(2-hydroxy-1-phenylethyl)-6-oxo-3-pyridinecarbonitrile
• CAS No.: 778602-85-0
• Molecular Formula: C₁₄H₁₄N₄O₂
• Molecular Weight: 270.291

Synonyms:2,4-diamino-1,6-dihydro-5-(2-hydroxy-1-phenylethyl)-6-oxo-3-pyridinecarbonitrile

Chemical Property of 2,4-diamino-1,6-dihydro-5-(2-hydroxy-1-phenylethyl)-6-oxo-3-pyridinecarbonitrile

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of 2,4-diamino-1,6-dihydro-5-(2-hydroxy-1-phenylethyl)-6-oxo-3-pyridinecarbonitrile

There total 2 articles about 2,4-diamino-1,6-dihydro-5-(2-hydroxy-1-phenylethyl)-6-oxo-3-pyridinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-(1-amino-2,2-dicyanoethenyl)-4-hydroxy-3-phenylbutanamide (778602-79-2) → 2,4-diamino-1,6-dihydro-5-(2-hydroxy-1-phenylethyl)-6-oxo-3-pyridinecarbonitrile (778602-85-0)

Guidance literature:

With methanesulfonic acid; In 1,4-dioxane; at 20 ℃; for 5h;

DOI:10.1002/jhet.5570410405

Reference yield:

2-amino-4,5-dihydro-4-phenyl-3-furancarboxamide (34884-15-6) → 2,4-diamino-1,6-dihydro-5-(2-hydroxy-1-phenylethyl)-6-oxo-3-pyridinecarbonitrile (778602-85-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / dioxane / 30 h / 60 °C

2: 73 percent / methanesulfonic acid / dioxane / 5 h / 20 °C

With methanesulfonic acid; In 1,4-dioxane;

DOI:10.1002/jhet.5570410405

Reference yield: 78.0%

2,4-diamino-1,6-dihydro-5-(2-hydroxy-1-phenylethyl)-6-oxo-3-pyridinecarbonitrile (778602-85-0) → 6-amino-2,3,4,5-tetrahydro-4-oxo-3-phenyl-furo[3,2-c]pyridine-7-carbonitrile

Guidance literature:

With methanesulfonic acid; In 1,4-dioxane; at 70 ℃; for 2h;

DOI:10.1002/jhet.5570410405

upstream raw materials:

2-(1-amino-2,2-dicyanoethenyl)-4-hydroxy-3-phenylbutanamide

2-amino-4,5-dihydro-4-phenyl-3-furancarboxamide

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