3-(4-(3-bromophenylamino)quinazolin-6-yloxy)propyl 4-methylpiperazine-1-carbodithioate

Base Information

Chemical Name:3-(4-(3-bromophenylamino)quinazolin-6-yloxy)propyl 4-methylpiperazine-1-carbodithioate
CAS No.:1259017-40-7
Molecular Formula:C₂₃H₂₆BrN₅OS₂
Molecular Weight:532.528
Hs Code.:

Synonyms:3-(4-(3-bromophenylamino)quinazolin-6-yloxy)propyl 4-methylpiperazine-1-carbodithioate

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Chemical Property of 3-(4-(3-bromophenylamino)quinazolin-6-yloxy)propyl 4-methylpiperazine-1-carbodithioate

Chemical Property:

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Technology Process of 3-(4-(3-bromophenylamino)quinazolin-6-yloxy)propyl 4-methylpiperazine-1-carbodithioate

There total 7 articles about 3-(4-(3-bromophenylamino)quinazolin-6-yloxy)propyl 4-methylpiperazine-1-carbodithioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 109-01-3
1-methyl-piperazine

: 75-15-0,12122-00-8
carbon disulfide

: 1259017-69-0
N-(3-bromophenyl)-6-(3-chloropropoxy)quinazolin-4-amine

: 1259017-40-7
3-(4-(3-bromophenylamino)quinazolin-6-yloxy)propyl 4-methylpiperazine-1-carbodithioate

Guidance literature:: 1-methyl-piperazine; With potassium phosphate; In N,N-dimethyl-formamide; for 0.25h;

carbon disulfide; In N,N-dimethyl-formamide; for 0.5h;

N-(3-bromophenyl)-6-(3-chloropropoxy)quinazolin-4-amine; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.04.096

Reference yield:

: 179688-15-4
4-hydroxyquinazoline-6-yl acetate

: 1259017-40-7
3-(4-(3-bromophenylamino)quinazolin-6-yloxy)propyl 4-methylpiperazine-1-carbodithioate

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / 6 h / Reflux

2.1: triethylamine / isopropyl alcohol / 4 h / Reflux

3.1: ammonia; water / methanol / 3 h / 20 °C

4.1: tetrabutylammomium bromide; potassium carbonate / acetonitrile / 0.33 h / Reflux

4.2: 2 h / Reflux

5.1: potassium phosphate / N,N-dimethyl-formamide / 0.25 h

5.2: 0.5 h

With potassium phosphate; thionyl chloride; tetrabutylammomium bromide; ammonia; water; potassium carbonate; triethylamine; N,N-dimethyl-formamide; In methanol; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;
DOI:10.1016/j.bmcl.2011.04.096

Reference yield:

: 1259017-68-9
4-((3-bromophenyl)amino)quinazolin-6-yl acetate

: 1259017-40-7
3-(4-(3-bromophenylamino)quinazolin-6-yloxy)propyl 4-methylpiperazine-1-carbodithioate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia; water / methanol / 3 h / 20 °C

2.1: tetrabutylammomium bromide; potassium carbonate / acetonitrile / 0.33 h / Reflux

2.2: 2 h / Reflux

3.1: potassium phosphate / N,N-dimethyl-formamide / 0.25 h

3.2: 0.5 h

With potassium phosphate; tetrabutylammomium bromide; ammonia; water; potassium carbonate; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2011.04.096