2-((R)-2-Methoxy-1-phenyl-ethylamino)-3,3-dimethyl-butyric acid ethyl ester

Base Information

• Chemical Name: 2-((R)-2-Methoxy-1-phenyl-ethylamino)-3,3-dimethyl-butyric acid ethyl ester
• CAS No.: 507229-71-2
• Molecular Formula: C₁₇H₂₇NO₃
• Molecular Weight: 293.406
• Mol file: 507229-71-2.mol

Synonyms:2-((R)-2-Methoxy-1-phenyl-ethylamino)-3,3-dimethyl-butyric acid ethyl ester

Chemical Property of 2-((R)-2-Methoxy-1-phenyl-ethylamino)-3,3-dimethyl-butyric acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((R)-2-Methoxy-1-phenyl-ethylamino)-3,3-dimethyl-butyric acid ethyl ester

There total 5 articles about 2-((R)-2-Methoxy-1-phenyl-ethylamino)-3,3-dimethyl-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

tert-butylzinc bromide (7565-59-5) + [(E)-(R)-2-Methoxy-1-phenyl-ethylimino]-acetic acid ethyl ester (110361-97-2) → 2-((R)-2-Methoxy-1-phenyl-ethylamino)-3,3-dimethyl-butyric acid ethyl ester (507229-71-2)

Guidance literature:

[(E)-(R)-2-Methoxy-1-phenyl-ethylimino]-acetic acid ethyl ester; With zinc dibromide; In diethyl ether; at 20 ℃; for 0.5h;

tert-butylzinc bromide; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 1h;

With ammonium chloride; In tetrahydrofuran; diethyl ether; water;

DOI:10.1016/S0957-4166(02)00587-6

Reference yield:

(R)-phenylglycine (875-74-1) → 2-((R)-2-Methoxy-1-phenyl-ethylamino)-3,3-dimethyl-butyric acid ethyl ester (507229-71-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: LiAlH₄ / tetrahydrofuran / Heating

2.1: MgSO₄ / CH₂Cl₂ / 2 h / 20 °C

3.1: NaH / tetrahydrofuran / 2.25 h / 20 - 40 °C

3.2: 85 percent / 3N HCl / tetrahydrofuran; diethyl ether / 3 h / 20 °C

4.1: MgSO₄ / CH₂Cl₂ / 1 h / 20 °C

5.1: ZnBr₂ / diethyl ether / 0.5 h / 20 °C

5.2: diethyl ether; tetrahydrofuran / 1 h / 0 - 20 °C

5.3: 68 percent / NH₄Cl / diethyl ether; H₂O; tetrahydrofuran

With lithium aluminium tetrahydride; sodium hydride; magnesium sulfate; zinc dibromide; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1016/S0957-4166(02)00587-6

Reference yield:

D-2-phenylglycinol (56613-80-0) → 2-((R)-2-Methoxy-1-phenyl-ethylamino)-3,3-dimethyl-butyric acid ethyl ester (507229-71-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: MgSO₄ / CH₂Cl₂ / 2 h / 20 °C

2.1: NaH / tetrahydrofuran / 2.25 h / 20 - 40 °C

2.2: 85 percent / 3N HCl / tetrahydrofuran; diethyl ether / 3 h / 20 °C

3.1: MgSO₄ / CH₂Cl₂ / 1 h / 20 °C

4.1: ZnBr₂ / diethyl ether / 0.5 h / 20 °C

4.2: diethyl ether; tetrahydrofuran / 1 h / 0 - 20 °C

4.3: 68 percent / NH₄Cl / diethyl ether; H₂O; tetrahydrofuran

With sodium hydride; magnesium sulfate; zinc dibromide; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1016/S0957-4166(02)00587-6

upstream raw materials:

tert-butylzinc bromide

[(E)-(R)-2-Methoxy-1-phenyl-ethylimino]-acetic acid ethyl ester

(R)-phenylglycine

D-2-phenylglycinol

Downstream raw materials:

ethyl (S)-2-amino-3,3-dimethylbutanoate

ethyl (R)-2-amino-3,3-dimethylbutanoate