tert-butyl N-[4-(aminocarbonyl)-3-iodobenzoyl]-O-tert-butyl-L-allothreoninate

Base Information

Chemical Name:tert-butyl N-[4-(aminocarbonyl)-3-iodobenzoyl]-O-tert-butyl-L-allothreoninate
CAS No.:857088-51-8
Molecular Formula:C₂₀H₂₉IN₂O₅
Molecular Weight:504.365
Hs Code.:

Synonyms:tert-butyl N-[4-(aminocarbonyl)-3-iodobenzoyl]-O-tert-butyl-L-allothreoninate

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Chemical Property of tert-butyl N-[4-(aminocarbonyl)-3-iodobenzoyl]-O-tert-butyl-L-allothreoninate

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Technology Process of tert-butyl N-[4-(aminocarbonyl)-3-iodobenzoyl]-O-tert-butyl-L-allothreoninate

There total 3 articles about tert-butyl N-[4-(aminocarbonyl)-3-iodobenzoyl]-O-tert-butyl-L-allothreoninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 857088-45-0
4-(aminocarbonyl)-3-iodobenzoic acid

: 5854-78-4,45171-63-9
O-tert.Butyl-L-threonin-tert.butylester

: 857088-51-8
tert-butyl N-[4-(aminocarbonyl)-3-iodobenzoyl]-O-tert-butyl-L-allothreoninate

Guidance literature:: With diphenyl-phosphinic acid; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 8h;
DOI:10.1021/jo050599r

Reference yield:

: 60728-41-8
1-methyl-2-aminoterephthalate

: 857088-51-8
tert-butyl N-[4-(aminocarbonyl)-3-iodobenzoyl]-O-tert-butyl-L-allothreoninate

Guidance literature:: Multi-step reaction with 3 steps

1: t-butyl nitrite; NaI; trifluoroacetic acid / acetonitrile; dimethylsulfoxide / 20 - 65 °C

2: 90 percent / ammonium hydroxide / H₂O / 12 h / 20 °C

3: 83 percent / DPPA; Et₃N / dimethylformamide / 8 h / 20 °C

With ammonium hydroxide; tert.-butylnitrite; diphenyl-phosphinic acid; triethylamine; trifluoroacetic acid; sodium iodide; In water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo050599r

Reference yield:

: 299173-24-3
[3-iodo-4-(methoxycarbonyl)]benzoic acid

: 857088-51-8
tert-butyl N-[4-(aminocarbonyl)-3-iodobenzoyl]-O-tert-butyl-L-allothreoninate

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / ammonium hydroxide / H₂O / 12 h / 20 °C

2: 83 percent / DPPA; Et₃N / dimethylformamide / 8 h / 20 °C

With ammonium hydroxide; diphenyl-phosphinic acid; triethylamine; In water; N,N-dimethyl-formamide;
DOI:10.1021/jo050599r