Technology Process of (2R,6R,7R)-4-Methylene-5,8-dioxo-7-(2-phenoxy-acetylamino)-5λ4-thia-1-aza-bicyclo[4.2.0]octane-2,2-dicarboxylic acid benzyl ester methyl ester
There total 11 articles about (2R,6R,7R)-4-Methylene-5,8-dioxo-7-(2-phenoxy-acetylamino)-5λ4-thia-1-aza-bicyclo[4.2.0]octane-2,2-dicarboxylic acid benzyl ester methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 75 percent / benzyltrimethylammonium hydroxide / dimethylformamide; methanol / -55 - 20 °C
2: 83 percent / benzyltrimethylammonium hydroxide / dimethylformamide; methanol / 2 h / 0 °C
3: 94 percent / iodine / CH2Cl2; H2O / 5.5 h / 20 °C
4: 52 percent / sodium periodate / methanol; H2O / 2.5 h / 35 °C
5: 308 mg / 1,8-diazobicyclo[5.4.0]undec-7-ene / CH2Cl2 / 1.5 h
With
sodium periodate; iodine; N-benzyl-trimethylammonium hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1139/v01-100
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 87 percent / trimethyl phosphite; magnesium sulfate / benzene / Heating
2: 62 percent / triethylamine / CH2Cl2 / 3 h
3: 78 percent / potassium permanganate; magnesium sulfate / H2O; ethanol
4: 75 percent / benzyltrimethylammonium hydroxide / dimethylformamide; methanol / -55 - 20 °C
5: 83 percent / benzyltrimethylammonium hydroxide / dimethylformamide; methanol / 2 h / 0 °C
6: 94 percent / iodine / CH2Cl2; H2O / 5.5 h / 20 °C
7: 52 percent / sodium periodate / methanol; H2O / 2.5 h / 35 °C
8: 308 mg / 1,8-diazobicyclo[5.4.0]undec-7-ene / CH2Cl2 / 1.5 h
With
potassium permanganate; sodium periodate; iodine; N-benzyl-trimethylammonium hydroxide; magnesium sulfate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; phosphorous acid trimethyl ester;
In
methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; benzene;
DOI:10.1139/v01-100
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 78 percent / potassium permanganate; magnesium sulfate / H2O; ethanol
2: 75 percent / benzyltrimethylammonium hydroxide / dimethylformamide; methanol / -55 - 20 °C
3: 83 percent / benzyltrimethylammonium hydroxide / dimethylformamide; methanol / 2 h / 0 °C
4: 94 percent / iodine / CH2Cl2; H2O / 5.5 h / 20 °C
5: 52 percent / sodium periodate / methanol; H2O / 2.5 h / 35 °C
6: 308 mg / 1,8-diazobicyclo[5.4.0]undec-7-ene / CH2Cl2 / 1.5 h
With
potassium permanganate; sodium periodate; iodine; N-benzyl-trimethylammonium hydroxide; magnesium sulfate; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1139/v01-100
![(1<i>R</i>)-3-phenoxymethyl-(1<i>r</i><i>H</i>,5<i>c</i><i>H</i>)-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-7-one](/Databaselist/images/loading.webp)
